Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Effect of Valerian/Hop Mixture on Sleep-Related Behaviors in Drosophila melanogaster

Authors
Choi, Hyeon-SonKo, Bong SooKim, Hae DunHong, Ki-BaeSuh, Hyung Joo
Issue Date
7월-2017
Publisher
PHARMACEUTICAL SOC JAPAN
Keywords
insomnia; sleep-promotion; Valerian; Hop; Drosophila melanogaster
Citation
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.40, no.7, pp.1101 - 1110
Indexed
SCIE
SCOPUS
Journal Title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume
40
Number
7
Start Page
1101
End Page
1110
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/82944
DOI
10.1248/bpb.b17-00262
ISSN
0918-6158
Abstract
The aim of this study was to investigate the sleep-promoting effect of a Valerian/Hops mixture in fruit flies. The HPLC analysis showed that Valerenic acid (1260.53 mu g/g of extract) and Xanthohumol (Cascade: 827.49 mu g/g, Hallertau: 763.60 mu g/g, Saaz: 186.93 mu g/g) were contained in Valerian and Hop, respectively. The sleep patterns of fruit flies on the Valerian/Hops were examined in both baseline and caffeine-treated conditions. Total activities of flies significantly decreased in 20 mg/mL Valerian (74%), 10 mg/mL Cascade (25%), and 5 mg/mL Hallertau (11%) during nighttime or daytime compared with the control. Valerian/Cascade mixture showed longer sleeping time (ca. 20%) than control group. This mixture-mediated effect was partly observed in caffeine-treated flies. Valerian/Cascade mixture upregulated mRNA expressions of gamma-aminobutyric acid (GABA) receptors and serotonin receptor, and GABA receptors were more strongly regulated than serotonin receptor. In competitive GABA receptor binding assay, Valerian/Cascade mixture extract showed a higher binding ability on GABA receptor than Valerenic acid or/and Xanthohumol which are estimated to be active compounds in the extract. This study demonstrates that a Valerian/Cascade mixture extract improves sleep-related behaviors, including sleeping time, by modulating GABAergic/serotonergic signaling.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Suh, Hyung Joo photo

Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE