Enabling techniques in the search for new antibiotics: Combinatorial biosynthesis of sugar-containing antibiotics
- Authors
- Park, Je Won; Nam, Sang-Jip; Yoon, Yeo Joon
- Issue Date
- 15-6월-2017
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Combinatorial biosynthesis; Sugar-containing antibiotics; Anti-infective and anti-proliferative
- Citation
- BIOCHEMICAL PHARMACOLOGY, v.134, pp.56 - 73
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL PHARMACOLOGY
- Volume
- 134
- Start Page
- 56
- End Page
- 73
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/83122
- DOI
- 10.1016/j.bcp.2016.10.009
- ISSN
- 0006-2952
- Abstract
- Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010-2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential. Finally, we present the feasible nexus between combinatorial biosynthesis, systems biology, and synthetic biology as a toolbox to provide new antibiotics that will be indispensable in the post-antibiotic era. (C) 2016 Elsevier Inc. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.