Clinical Significance of 5-Fluorouracil Chemosensitivity Testing in Patients with Colorectal Cancer
- Authors
- Ji, Woong Bae; Um, Jun Won; Ryu, Je Seock; Hong, Kwang Dae; Kim, Jung Sik; Min, Byung Wook; Joung, Sung Yeop; Lee, Ju Han; Kim, Young Sik
- Issue Date
- 5월-2017
- Publisher
- INT INST ANTICANCER RESEARCH
- Keywords
- Colorectal cancer; chemotherapy; chemosensitivity; 5-fluorouracil; survival
- Citation
- ANTICANCER RESEARCH, v.37, no.5, pp.2679 - 2682
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANTICANCER RESEARCH
- Volume
- 37
- Number
- 5
- Start Page
- 2679
- End Page
- 2682
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/83521
- DOI
- 10.21873/anticanres.11616
- ISSN
- 0250-7005
- Abstract
- Aim: To evaluate whether the results of chemosensitivity testing were associated with prognosis of colorectal cancer patients after adjuvant 5-fluorouracil (FU)/ leucovorin chemotherapy. Patients and Methods: Eighty-nine patients who received 5-FU/leucovorin adjuvant chemotherapy for colorectal cancer were enrolled. Chemosensitivity tests were performed and tumor growth inhibition rate was calculated using the MTT (3-(4,5dimethylthiazol-2-yl)02,5-diphenyl-2H tetrazolium bromide) assay. Results: Fifty-one patients (57.3%) were sensitive to 5-FU according to the chemosensitivity test. After a median follow-up of 64 months, there was a significant difference between the 5-year disease-free survival rates of the chemosensitive and chemo-resistant groups. However, there was no significant difference in the overall 5-year survival between the chemo-sensitive and chemo-resistant groups. Conclusion: A positive 5-FU sensitivity test with in vitro histoculture drug response assay (HDRA) was associated with better disease-free survival. Chemosensitivity may be a prognostic factor for colorectal cancer patients undergoing adjuvant 5-FU/leucovorin chemotherapy.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.