MR and mammographic imaging features of HER2-positive breast cancers according to hormone receptor status: a retrospective comparative study
- Authors
- Sung Eun Song; Song Sung Eun
- Issue Date
- Jan-2017
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- human epidermal growth factor receptor 2 (HER2); hormone receptors; mammography; magnetic resonance imaging (MRI); Breast tumors
- Citation
- ACTA RADIOLOGICA, v.58, no.7, pp.792 - 799
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACTA RADIOLOGICA
- Volume
- 58
- Number
- 7
- Start Page
- 792
- End Page
- 799
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/83824
- DOI
- 10.1177/0284185116673119
- ISSN
- 0284-1851
- Abstract
- Background: Human epidermal growth factor receptor 2-positive (HER2+) breast cancer has two distinct subtypes according to hormone receptor (HR) status. Survival, pattern of recurrence, and treatment response differ between HR-/HER2+ and HR+/HER2+ cancers. Purpose: To investigate imaging and clinicopathologic features of HER2+ cancers and their correlation with HR expression. Material and Methods: Between 2011 and 2013, 252 consecutive patients with 252 surgically confirmed HER2+ cancers (125 HR- and 127 HR+) were included. Two experienced breast radiologists blinded to the clinicopathologic findings reviewed the mammograms and magnetic resonance (MR) images using the BI-RADS lexicon. Tumor kinetic features were acquired by computer-aided detection (CAD). The imaging and clinicopathologic features of 125 HR-/HER2+ cancers were compared with those of 127 HR+/HER2+ cancers. Association between the HR status and each feature was assessed. Results: Multiple logistic regression analysis showed that circumscribed mass margin (odds ratio [OR], 4.73; P< 0.001), associated non-mass enhancement (NME) on MR images (OR, 3.29; P = 0.001), high histologic grade (OR, 3.89; P = 0.002), high Ki-67 index (OR, 3.06; P = 0.003), and older age (OR, 2.43; P = 0.006) remained independent indicators ass
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