Distinct Fragmentation Pathways of Anticancer Drugs Induced by Charge-Carrying Cations in the Gas Phase
- Authors
- Hong, Areum; Lee, Hong Hee; Heo, Chae Eun; Cho, Yunju; Kim, Sunghwan; Kang, Dukjin; Kim, Hugh I.
- Issue Date
- 4월-2017
- Publisher
- SPRINGER
- Keywords
- Structural elucidation; Anticancer drug; Tandem mass spectrometry; Fragmentation; Doxorubicin; Vinblastine; Vinorelbine; Proton; Alkali metal; Ion mobility mass spectrometry; Theoretical calculation
- Citation
- JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, v.28, no.4, pp.628 - 637
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Volume
- 28
- Number
- 4
- Start Page
- 628
- End Page
- 637
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/84031
- DOI
- 10.1007/s13361-016-1559-x
- ISSN
- 1044-0305
- Abstract
- With the growth of the pharmaceutical industry, structural elucidation of drugs and derivatives using tandem mass spectrometry (MS2) has become essential for drug development and pharmacokinetics studies because of its high sensitivity and low sample requirement. Thus, research seeking to understand fundamental relationships between fragmentation patterns and precursor ion structures in the gas phase has gained attention. In this study, we investigate the fragmentation of the widely used anticancer drugs, doxorubicin (DOX), vinblastine (VBL), and vinorelbine (VRL), complexed by a singly charged proton or alkali metal ion (Li+, Na+, K+) in the gas phase. The drug-cation complexes exhibit distinct fragmentation patterns in tandem mass spectra as a function of cation size. The trends in fragmentation patterns are explicable in terms of structures derived from ion mobility mass spectrometry (IM-MS) and theoretical calculations.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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