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A bioorthogonal 'turn-on' fluorescent probe for tracking mitochondrial nitroxyl formation
- Authors
- Sunwoo, Kyoung; Bobba, Kondapa Naidu; Lim, Ja-Yun; Park, Taegun; Podder, Arup; Heo, June Seok; Lee, Seung Gwan; Bhuniya, Sankarprasad L; Kim, Jong Seung
- Issue Date
- 4-2월-2017
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.53, no.10, pp.1723 - 1726
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 53
- Number
- 10
- Start Page
- 1723
- End Page
- 1726
- ISSN
- 1359-7345
- Abstract
- A bioreductant-resistant 'turn-on' chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as similar to 18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a non-invasive imaging tool for the detection of mitochondrial nitroxyl.
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