Trichosanthes kirilowil Exerts Androgenic Activity via Regulation of PSA and KLK2 in 22Rv1 Prostate Cancer Cells
- Authors
- Jeong, Soo-Jin; Chop, Ji-Yoon; Dong, Mi-Sook; Seo, Chang-Seob; Shin, Hyeun-Kyoo
- Issue Date
- 1월-2017
- Publisher
- MEDKNOW PUBLICATIONS & MEDIA PVT LTD
- Keywords
- Androgen; androgen receptor; transcription; Trichosantheskirilowii; 22Rv1 cells
- Citation
- PHARMACOGNOSY MAGAZINE, v.13, no.49, pp.153 - 158
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHARMACOGNOSY MAGAZINE
- Volume
- 13
- Number
- 49
- Start Page
- 153
- End Page
- 158
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/85059
- DOI
- 10.4103/0973-1296.197657
- ISSN
- 0973-1296
- Abstract
- Background: The androgen comprises a group of hormones that play roles in male reproductive activity as well as personal characteristics. Objective: We investigated the androgenic activity of various herbal medicines in human prostate cancer 22Rv1 cells. Materials and Methods: Herbal extracts of Trichosanthes kirilowii (TK), Asarum sieboldii (AS), Sanguisorba officinalis (SO), and Xanthium strumarium (XS) were selected to have androgenic effects based on a preliminary in vitro screening system. Results: TK, AS, SO, and XS enhanced the proliferation of 22Rv1 cells without having cytotoxic effects. All tested herbal extracts increased androgen receptor (AR)-induced transcriptional activity in the absence or presence of dihydrotestosterone (DHT). In an AR-binding assay, TK, but not AS, SO, or XS, produced a significant inhibition of AR binding activity, indicating it has androgenic activity. Additionally, TK treatment positively regulated mRNA expression of the AR-related molecular targets prostate-specific antigen (PSA) and kallikrein 2 (KLK2) compared with untreated control. Conclusion: Taken together, TK-enhanced AR-mediated transcriptional activity might be an attractive candidate drug for treating androgen-related diseases.
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