Effects of gangliosides from deer bone extract on the gene expressions of matrix metalloproteinases and collagen type II in interleukin-1 beta-induced osteoarthritic chondrocytes
DC Field | Value | Language |
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dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Lee, Hyunji | - |
dc.contributor.author | Min, Byung Jung | - |
dc.contributor.author | Jung, Sung Ug | - |
dc.contributor.author | Jung, Eun Young | - |
dc.date.accessioned | 2021-09-03T16:06:55Z | - |
dc.date.available | 2021-09-03T16:06:55Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 1976-1457 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/86617 | - |
dc.description.abstract | BACKGROUND/OBJECTIVES: We investigated the anti-osteoarthritic effects of deer bone extract on the gene expressions of matrix metalloproteinases (MMPs) and collagen type II (COL2) in interleukin-1 beta-induced osteoarthritis (OA) chondrocytes. MATERIALS/METHODS: Primary rabbit chondrocytes were treated as follows: CON (PBS treatment), NC (IL-1 beta treatment), PC (IL-1 beta + 100 mu g/mL glucosamine sulphate/chondroitin sulphate mixture), and DB (IL-1 beta + 100 mu g/mL. deer bone extract). RESULTS: The results of the cell viability assay indicated that deer bone extract at doses ranging from 100 to 500 mu g/mL inhibits cell death in chondrocytes induced by IL-1 beta. Deer bone extract was able to significantly recover the mRNA expression of COL2 that was down-regulated by IL-1 beta (NC: 0.79 vs. DB: 0.87, P < 0.05) and significantly decrease the mRNA expression of MMP-3 (NC: 2.24 vs. DB: 1.75) and -13 (NC: 1.28 vs. DB: 0.89) in OA chondrocytes (P < 0.05). CONCLUSIONS: We concluded that deer bone extract induces accumulation of COL2 through the down-regulation of MMPs in IL-1 beta-induced OA chondrocytes. Our results suggest that deer bone extract, which contains various components related to OA, including chondroitin sulphate, may possess anti-osteoarthritic properties and be of value in inhibiting the pathogenesis of OA. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NUTRITION SOC | - |
dc.subject | CHONDROITIN SULFATE PROTEOGLYCAN | - |
dc.subject | ARTICULAR-CARTILAGE | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | DEGRADATION | - |
dc.subject | OSTEOBLASTS | - |
dc.subject | GLUCOSAMINE | - |
dc.subject | DEPLETION | - |
dc.subject | ANTLERS | - |
dc.subject | CELLS | - |
dc.subject | ASSAY | - |
dc.title | Effects of gangliosides from deer bone extract on the gene expressions of matrix metalloproteinases and collagen type II in interleukin-1 beta-induced osteoarthritic chondrocytes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.4162/nrp.2016.10.6.569 | - |
dc.identifier.scopusid | 2-s2.0-85006314611 | - |
dc.identifier.wosid | 000389168600001 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH AND PRACTICE, v.10, no.6, pp.569 - 574 | - |
dc.relation.isPartOf | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.title | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 569 | - |
dc.citation.endPage | 574 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002165908 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | CHONDROITIN SULFATE PROTEOGLYCAN | - |
dc.subject.keywordPlus | ARTICULAR-CARTILAGE | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | OSTEOBLASTS | - |
dc.subject.keywordPlus | GLUCOSAMINE | - |
dc.subject.keywordPlus | DEPLETION | - |
dc.subject.keywordPlus | ANTLERS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ASSAY | - |
dc.subject.keywordAuthor | Chondrocytes | - |
dc.subject.keywordAuthor | collagen type II | - |
dc.subject.keywordAuthor | interleukin-1 beta | - |
dc.subject.keywordAuthor | matrix metalloproteinases | - |
dc.subject.keywordAuthor | osteoarthritis | - |
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