Hypoglycemia is associated with dementia in elderly patients with type 2 diabetes mellitus: An analysis based on the Korea National Diabetes Program Cohort
- Authors
- Chin, Sang Ouk; Rhee, Sang Youl; Chon, Suk; Baik, Sei Hyun; Park, Yongsoo; Nam, Moon Suk; Lee, Kwan Woo; Chun, Ki Hong; Woo, Jeong-taek; Kim, Young Seol
- Issue Date
- 12월-2016
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Hypoglycemia; Dementia; Type 2 diabetes
- Citation
- DIABETES RESEARCH AND CLINICAL PRACTICE, v.122, pp.54 - 61
- Indexed
- SCIE
SCOPUS
- Journal Title
- DIABETES RESEARCH AND CLINICAL PRACTICE
- Volume
- 122
- Start Page
- 54
- End Page
- 61
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/86626
- DOI
- 10.1016/j.diabres.2016.09.027
- ISSN
- 0168-8227
- Abstract
- Aim: Although hypoglycemia is associated with cognitive dysfunction, including dementia, in patients with type 2 diabetes mellitus (DM), the data are equivocal. The purpose of this study was to investigate the association between hypoglycemia, dementia, and other cognitive dysfunctions. Methods: This was a prospective observational study based upon the Korea National Diabetes Program (KNDP). Among the 4540 participants in the KNDP cohort, individuals aged >= 60 years without any history of hypoglycemia or cognitive dysfunction (n = 1957) were included. Nationally representative data from the Health Insurance Review and Assessment Service of Korea claim database were used to obtain a more precise determination of patient outcome. Results: During a mean follow-up period of 3.4 +/- 0.9 years, 118 subjects experienced hypoglycemia-related events. The incidence of dementia and cognitive dysfunction was 7.5 cases per 1000 person-years (PY) and 0.61 cases per 1000 PY, respectively. In the subjects who experienced hypoglycemic events (relative to those who did not), the incidence of dementia was significantly higher (P = 0.0139), but the incidence of cognitive dysfunction was not (P = 0.1106). Hypoglycemic events were associated with dementia (HR, 2.689; 95% CI, 1.080-6.694, P = 0.0335) following multiple adjustments. There was also a significant linear trend toward an increased dementia risk commensurate with an increasing number of hypoglycemic events (P = 0.0286). Conclusions: Hypoglycemia is significantly associated with the risk of dementia in Korean type 2 DM patients aged >= 60 years. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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