Antimicrobial activity of a novel furan fatty acid, 7,10-epoxyoctadeca-7,9-dienoic acid against methicillin-resistant Staphylococcus aureus
- Authors
- Dasagrandhi, Chakradhar; Ellamar, Joel B.; Kim, Young Soon; Kim, Hak-Ryul
- Issue Date
- Dec-2016
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- furan fatty acids; 7,10-epoxyoctadeca-7,9-dienoic acid; antimicrobial lipids; methicillin-resistant Staphylococcus aureus; virulence inhibition
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.25, no.6, pp.1671 - 1675
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 25
- Number
- 6
- Start Page
- 1671
- End Page
- 1675
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/86697
- DOI
- 10.1007/s10068-016-0257-6
- ISSN
- 1226-7708
- Abstract
- We analyzed the antimicrobial potential of a novel furan fatty acid, 7,10-epoxyoctadeca-7,9-dienoic acid (7,10-EODA) against methicillin-resistant and-sensitive S. aureus (MRSA and MSSA). The anti-staphylococcal activity of 7,10-EODA and its consequences on cell physiology was determined by disc diffusion, broth microdilution, and flow cytometry. Anti-virulence activity of 7,10-EODA was evaluated by bioassays. 7,10-EODA was anti-staphylococcal with minimum inhibitory concentration (MIC) range of 125-250 mg/L. 7,10-EODA exhibited a dose response and inhibited MRSA 01ST001 by 90.5% and ATCC 29213 (MSSA) by 85.3% at 125 mg/L. MIC of 7,10-EODA permeabilized >95 % of MRSA 01ST001 cells to small molecules. Sublethal dose of 7,10-EODA was non-toxic but markedly reduced the hemolytic, coagulase, and autolytic activities of MRSA and MSSA at 15.6 mg/L. The results provide a lead for the utilization of natural furan fatty acids as novel anti-MRSA agents.
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