Quercetin intake, MATE1 polymorphism, and metabolic syndrome in Korean population: Hallym aging study
- Authors
- Lee, Jung Eun; Park, Hye Won; Lee, Jae Kyung; Mok, Bo Ram; Lee, Hae-Jeung; Lee, Sung-Joon; Kim, Dong-Hyun
- Issue Date
- 12월-2016
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- quercetin; metabolic syndrome; multidrug and toxic compound extrusion transporter-1; flavonoid
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.25, no.6, pp.1783 - 1788
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 25
- Number
- 6
- Start Page
- 1783
- End Page
- 1788
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/86705
- DOI
- 10.1007/s10068-016-0271-8
- ISSN
- 1226-7708
- Abstract
- Multidrug and toxic compound extrusion transporter-1 (MATE1) is a quercetin transporter. We examined the associations of quercetin intake and polymorphism of MATE1 in relation to metabolic syndrome (MetS) in Hallym Aging Study. Quercetin intake and the measurements for MetS were assessed in 2004. Six tagging single nucleotide polymorphisms (SNPs) at MATE1 gene were genotyped in 428 Korean adults in 2012. We found a lower prevalence of MetS with quercetin intake; compared to the lowest quartile, odds ratios (ORs, 95% confidence intervals; Cls) were 0.44 (0.24-0.84) for the 3rd quartile. Individuals with the minor allele of MATE1, rs2453589, tended to have a lower prevalence of MetS compared to those with the major allele (OR=0.69; CI=0.36-1.34). However, interactions between quercetin intake and six MATE1 polymorphisms in relation to MetS were not significant (p for interaction >= 0.37). In conclusion, intake of quercetin was associated with MetS in Korean populations.
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