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Two-Photon Tracer for Human Epidermal Growth Factor Receptor-2: Detection of Breast Cancer in a Live Tissue
- Authors
- Choi, Ji-Woo; Hong, Seung Taek; Kang, Dong Eun; Paik, Kyu Cheol; Han, Man So; Lim, Chang Su; Cho, Bong Rae
- Issue Date
- 4-10월-2016
- Publisher
- AMER CHEMICAL SOC
- Citation
- ANALYTICAL CHEMISTRY, v.88, no.19, pp.9412 - 9418
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANALYTICAL CHEMISTRY
- Volume
- 88
- Number
- 19
- Start Page
- 9412
- End Page
- 9418
- ISSN
- 0003-2700
- Abstract
- We have developed a two-photon fluorescent tracer (Pyr-affibody) that shows high selectivity for human epidermal growth factor receptor-2 (HER-2). Pyr-affibody showed absorption and emission maxima at 439 and 574 nm, respectively, with a two photon absorption cross-section value of 40 X 10(-50) cm(4)s/photon (GM) at 750 nm in aqueous buffer solution. The effective two photon action cross-section value measured in HeLa cells was 600 GM at 730 nm, a value sufficient to obtain bright two-photon microscopy (TPM) images. Using Pyr-affibody, it was possible to detect HER-2 overexpressing cells and breast cancers at a depth of 90-130 mu m in live mouse tissue by TPM.
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