Brief Communication: SIR-2.1-dependent lifespan extension of Caenorhabditis elegans by oxyresveratrol and resveratrol
- Authors
- Lee, Jiyun; Kwon, Gayeung; Park, Jieun; Kim, Jeong-Keun; Lim, Young-Hee
- Issue Date
- Oct-2016
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Oxyresveratrol; SIR-2; 1; lifespan; Caenorhabditis elegans; resveratrol
- Citation
- EXPERIMENTAL BIOLOGY AND MEDICINE, v.241, no.16, pp.1757 - 1763
- Indexed
- SCIE
SCOPUS
- Journal Title
- EXPERIMENTAL BIOLOGY AND MEDICINE
- Volume
- 241
- Number
- 16
- Start Page
- 1757
- End Page
- 1763
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/87235
- DOI
- 10.1177/1535370216650054
- ISSN
- 1535-3702
- Abstract
- Resveratrol (RES) has been studied for its effects on the lifespan extension of Caenorhabditis elegans, but controversy still remains on its mechanism related with SIR-2. In this study, longevity assay was performed to confirm SIR-2-dependent lifespan extension of C. elgeans with RES and oxyresveratrol (OXY), an isomer of hydroxylated RES using loss-of-function mutants of C. elegans including sir-2.1 mutant. The results showed that OXY and RES significantly (P<0.05) extended the lifespan of C. elegans compared with the control. OXY and RES also significantly (P<0.05) increased the mRNA expression levels of sir-2.1 and aak-2 in a dose-dependent manner and increased the protein expression levels of SIR-2.1. OXY and RES treatment extended the lifespan in daf-16 loss-of-function mutants, which suggested that lifespan extension was not occurring via the activation of DAF-16. However, OXY and RES failed to extend the lifespan in loss-of-function mutants of sir-2.1 and aak-2. Therefore, OXY and RES extend the lifespan of C. elegans by overexpression of SIR-2.1, which is related to lifespan extension through calorie restriction and the AMP-activated protein kinase (AMPK) pathway, although this process is independent of the FOXO/DAF-16 pathway.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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