Sleep-promoting effects of the GABA/5-HTP mixture in vertebrate models
DC Field | Value | Language |
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dc.contributor.author | Hong, Ki-Bae | - |
dc.contributor.author | Park, Yooheon | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2021-09-03T20:10:36Z | - |
dc.date.available | 2021-09-03T20:10:36Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-09-01 | - |
dc.identifier.issn | 0166-4328 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87553 | - |
dc.description.abstract | The aim of this study was to investigate the sleep-promoting effect of combined gamma-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP) on sleep quality and quantity in vertebrate models. Pentobarbital-induced sleep test and electroencephalogram (EEG) analysis were applied to investigate sleep latency, duration, total sleeping time and sleep quality of two amino acids and GABA/5-HTP mixture. In addition, real-time PCR and HPLC analysis were applied to analyze the signaling pathway. The GABA/5-HTP mixture significantly regulated the sleep latency, duration (p < 0.005), and also increased the sleep quality than single administration of the amino acids (p < 0.000). Long-term administration increased the transcript levels of GABA(A) receptor (1.37-fold, p < 0.000) and also increased the GABA content compared with the control group 12 h after administration (1.43-fold, p < 0.000). Our available evidence suggests that the GABA/5-HTP mixture modulates both GABAergic and serotonergic signaling. Moreover, the sleep architecture can be controlled by the regulation of GABA(A) receptor and GABA content with 5-HTP. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | OREXIN RECEPTOR ANTAGONISTS | - |
dc.subject | PONTINE RETICULAR-FORMATION | - |
dc.subject | REM-SLEEP | - |
dc.subject | ACETYLCHOLINE-RELEASE | - |
dc.subject | MICE | - |
dc.subject | EXPRESSION | - |
dc.subject | INSOMNIA | - |
dc.subject | RAT | - |
dc.subject | WAKEFULNESS | - |
dc.subject | ACTIVATION | - |
dc.title | Sleep-promoting effects of the GABA/5-HTP mixture in vertebrate models | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1016/j.bbr.2016.04.049 | - |
dc.identifier.scopusid | 2-s2.0-84966417117 | - |
dc.identifier.wosid | 000378958800005 | - |
dc.identifier.bibliographicCitation | BEHAVIOURAL BRAIN RESEARCH, v.310, pp.36 - 41 | - |
dc.relation.isPartOf | BEHAVIOURAL BRAIN RESEARCH | - |
dc.citation.title | BEHAVIOURAL BRAIN RESEARCH | - |
dc.citation.volume | 310 | - |
dc.citation.startPage | 36 | - |
dc.citation.endPage | 41 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Behavioral Sciences | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Behavioral Sciences | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | OREXIN RECEPTOR ANTAGONISTS | - |
dc.subject.keywordPlus | PONTINE RETICULAR-FORMATION | - |
dc.subject.keywordPlus | REM-SLEEP | - |
dc.subject.keywordPlus | ACETYLCHOLINE-RELEASE | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INSOMNIA | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | WAKEFULNESS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | Sleep | - |
dc.subject.keywordAuthor | gamma-Aminobutyric acid | - |
dc.subject.keywordAuthor | 5-Hydroxytryptophan | - |
dc.subject.keywordAuthor | Pentobarbital | - |
dc.subject.keywordAuthor | Electroencephalogram | - |
dc.subject.keywordAuthor | Vertebrate | - |
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