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Sleep-promoting effects of the GABA/5-HTP mixture in vertebrate models

Authors
Hong, Ki-BaePark, YooheonSuh, Hyung Joo
Issue Date
1-9월-2016
Publisher
ELSEVIER SCIENCE BV
Keywords
Sleep; gamma-Aminobutyric acid; 5-Hydroxytryptophan; Pentobarbital; Electroencephalogram; Vertebrate
Citation
BEHAVIOURAL BRAIN RESEARCH, v.310, pp.36 - 41
Indexed
SCIE
SCOPUS
Journal Title
BEHAVIOURAL BRAIN RESEARCH
Volume
310
Start Page
36
End Page
41
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/87553
DOI
10.1016/j.bbr.2016.04.049
ISSN
0166-4328
Abstract
The aim of this study was to investigate the sleep-promoting effect of combined gamma-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP) on sleep quality and quantity in vertebrate models. Pentobarbital-induced sleep test and electroencephalogram (EEG) analysis were applied to investigate sleep latency, duration, total sleeping time and sleep quality of two amino acids and GABA/5-HTP mixture. In addition, real-time PCR and HPLC analysis were applied to analyze the signaling pathway. The GABA/5-HTP mixture significantly regulated the sleep latency, duration (p < 0.005), and also increased the sleep quality than single administration of the amino acids (p < 0.000). Long-term administration increased the transcript levels of GABA(A) receptor (1.37-fold, p < 0.000) and also increased the GABA content compared with the control group 12 h after administration (1.43-fold, p < 0.000). Our available evidence suggests that the GABA/5-HTP mixture modulates both GABAergic and serotonergic signaling. Moreover, the sleep architecture can be controlled by the regulation of GABA(A) receptor and GABA content with 5-HTP. (C) 2016 Elsevier B.V. All rights reserved.
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Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
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