Antiobesity Effect of Garlic Extract Fermented by Lactobacillus plantarum BL2 in Diet-Induced Obese Mice
DC Field | Value | Language |
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dc.contributor.author | Lee, Hee-Seop | - |
dc.contributor.author | Lim, Won-Chul | - |
dc.contributor.author | Lee, Sung-Jin | - |
dc.contributor.author | Lee, Seung-Hyun | - |
dc.contributor.author | Lee, Jin-Hyup | - |
dc.contributor.author | Cho, Hong-Yon | - |
dc.date.accessioned | 2021-09-03T20:39:17Z | - |
dc.date.available | 2021-09-03T20:39:17Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87697 | - |
dc.description.abstract | Obesity is viewed as a serious public health problem. This study aimed to investigate the antiobesity effects of fermented garlic extract by lactic acid bacteria (LAFGE) on obesity. Male C57BL/6J mice were fed with high-fat diet (HFD) to induce obesity. The HFD-induced obese mice were orally administrated with 250 or 500 mg/kg LAFGE for 8 weeks. Feeding HFD-fed mice with 250 or 500 mg/kg LAFGE reduced body weight by 14% and 18%, respectively, compared to HFD. HFD-fed mice with 500mg/kg LAFGE administration had lower epididymal, retroperitoneal, and mesenteric adipose tissue mass by 36%, 44%, and 63%, respectively, compared to HFD. The concentration of plasma triacylglyceride and total cholesterol was significantly lower in the HFD-fed mice with LAFGE administration. Moreover, LAFGE supplementation suppressed adipogenesis by downregulation in mRNA and protein expression of PPAR gamma, C/EBP alpha, and lipogenic proteins, including SREBP-1c, FAS, and SCD-1. Based on these findings, LAFGE may ameliorate diet-induced obesity by inhibiting adipose tissue hypertrophy by suppressing adipogenesis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | CYSTEINE-CONTAINING COMPOUNDS | - |
dc.subject | ALLIUM-SATIVUM L. | - |
dc.subject | FAT | - |
dc.subject | ADIPOGENESIS | - |
dc.subject | ADIPOCYTE | - |
dc.subject | PREADIPOCYTES | - |
dc.subject | BIOSYNTHESIS | - |
dc.subject | CHOLESTEROL | - |
dc.subject | EXPRESSION | - |
dc.subject | BIOLOGY | - |
dc.title | Antiobesity Effect of Garlic Extract Fermented by Lactobacillus plantarum BL2 in Diet-Induced Obese Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jin-Hyup | - |
dc.contributor.affiliatedAuthor | Cho, Hong-Yon | - |
dc.identifier.doi | 10.1089/jmf.2016.3674 | - |
dc.identifier.scopusid | 2-s2.0-84988443759 | - |
dc.identifier.wosid | 000383965500002 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, v.19, no.9, pp.823 - 829 | - |
dc.relation.isPartOf | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.title | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.volume | 19 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 823 | - |
dc.citation.endPage | 829 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002148500 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | CYSTEINE-CONTAINING COMPOUNDS | - |
dc.subject.keywordPlus | ALLIUM-SATIVUM L. | - |
dc.subject.keywordPlus | FAT | - |
dc.subject.keywordPlus | ADIPOGENESIS | - |
dc.subject.keywordPlus | ADIPOCYTE | - |
dc.subject.keywordPlus | PREADIPOCYTES | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | CHOLESTEROL | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordAuthor | antiobesity | - |
dc.subject.keywordAuthor | fermented foods | - |
dc.subject.keywordAuthor | garlic | - |
dc.subject.keywordAuthor | Lactobacillus (Acidophilus, Bulgaricus, and others) | - |
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