Plantamajoside Inhibits UVB and Advanced Glycation End Products-Induced MMP-1 Expression by Suppressing the MAPK and NF-B Pathways in HaCaT Cells
DC Field | Value | Language |
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dc.contributor.author | Han, Ah-Ram | - |
dc.contributor.author | Nam, Mi-Hyun | - |
dc.contributor.author | Lee, Kwang-Won | - |
dc.date.accessioned | 2021-09-03T20:47:44Z | - |
dc.date.available | 2021-09-03T20:47:44Z | - |
dc.date.created | 2021-06-16 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 0031-8655 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/87718 | - |
dc.description.abstract | Photoaging and glycation stress are major causes of skin deterioration. Oxidative stress caused by ultraviolet B (UVB) irradiation can upregulate matrix metalloprotease 1 (MMP-1), a major enzyme responsible for collagen damage in the skin. Advanced glycation end products (AGEs) accumulate via gradual formation from skin proteins, especially from long-lived proteins such as dermal elastin and collagen. Plantamajoside (PM), isolated from Plantago asiatica, has various biological effects including anti-inflammatory and antioxidant effects. In this study, we assessed the protective effects of PM on a human keratinocyte cell line (HaCaT) and primary human dermal fibroblasts (HDF) against stress caused by glyceraldehyde-induced AGEs (glycer-AGEs) with UVB irradiation. We found that PM attenuated UVB- and-glycer-AGEs-induced MMP-1 expression in HaCaT and HDF cells and proinflammatory cytokines expression by inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs) activated by reactive oxygen species. Specific inhibitors of NF-B and MAPKs attenuated the induced expression of MMP-1. PM also inhibited the phosphorylation of IB, and reduced nuclear translocation of NF-B in these cells. Furthermore, PM attenuated the upregulation of receptor for AGEs (RAGE) by glycer-AGEs with UVB irradiation. Therefore, our findings strongly suggest that PM is a promising inhibitor of skin photoaging. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | ACTIVATED PROTEIN-KINASE | - |
dc.subject | INDUCED LIPID-PEROXIDATION | - |
dc.subject | HUMAN DERMAL FIBROBLASTS | - |
dc.subject | HUMAN SKIN FIBROBLASTS | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | FACTOR-KAPPA-B | - |
dc.subject | MATRIX METALLOPROTEINASE-1 | - |
dc.subject | EPIDERMAL-KERATINOCYTES | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.title | Plantamajoside Inhibits UVB and Advanced Glycation End Products-Induced MMP-1 Expression by Suppressing the MAPK and NF-B Pathways in HaCaT Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kwang-Won | - |
dc.identifier.doi | 10.1111/php.12615 | - |
dc.identifier.scopusid | 2-s2.0-84988000483 | - |
dc.identifier.wosid | 000383597300008 | - |
dc.identifier.bibliographicCitation | PHOTOCHEMISTRY AND PHOTOBIOLOGY, v.92, no.5, pp.708 - 719 | - |
dc.relation.isPartOf | PHOTOCHEMISTRY AND PHOTOBIOLOGY | - |
dc.citation.title | PHOTOCHEMISTRY AND PHOTOBIOLOGY | - |
dc.citation.volume | 92 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 708 | - |
dc.citation.endPage | 719 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | INDUCED LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | HUMAN DERMAL FIBROBLASTS | - |
dc.subject.keywordPlus | HUMAN SKIN FIBROBLASTS | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASE-1 | - |
dc.subject.keywordPlus | EPIDERMAL-KERATINOCYTES | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
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