Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Dual function of MG53 in membrane repair and insulin signaling
- Authors
- Tan, Tao; Ko, Young-Gyu; Ma, Jianjie
- Issue Date
- 31-8월-2016
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Keywords
- MG53; TRIM72; E3 ligase; Muscular Dystrophy; Membrane Repair; Insulin Resistance
- Citation
- BMB REPORTS, v.49, no.8, pp.414 - 423
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BMB REPORTS
- Volume
- 49
- Number
- 8
- Start Page
- 414
- End Page
- 423
- ISSN
- 1976-6696
- Abstract
- MG53 is a member of the TRIM-family protein that acts as a key component of the cell membrane repair machinery. MG53 is also an E3-ligase that ubiquinates insulin receptor substrate-1 and controls insulin signaling in skeletal muscle cells. Since its discovery in 2009, research efforts have been devoted to translate this basic discovery into clinical applications in human degenerative and metabolic diseases. This review article highlights the dual function of MG53 in cell membrane repair and insulin signaling, the mechanism that underlies the control of MG53 function, and the therapeutic value of targeting MG53 function in regenerative medicine.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.