Diffusion-Induced Hydrophilic Conversion of Polydimethylsiloxane/Block-Type Phospholipid Polymer Hybrid Substrate for Temporal Cell-Adhesive Surface
- Authors
- Seo, Ji-Hun; Ishihara, Kazuhiko
- Issue Date
- 24-8월-2016
- Publisher
- AMER CHEMICAL SOC
- Keywords
- poly(2-methacryloyloxyethyl phosphorylcholine); polydimethylsiloxane; swelling-deswelling process; hybrid material; cell adhesion
- Citation
- ACS APPLIED MATERIALS & INTERFACES, v.8, no.33, pp.21839 - 21846
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS APPLIED MATERIALS & INTERFACES
- Volume
- 8
- Number
- 33
- Start Page
- 21839
- End Page
- 21846
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/87790
- DOI
- 10.1021/acsami.6b07414
- ISSN
- 1944-8244
- Abstract
- In this study, diffusion-induced hydrophobic hydrophilic conversion of the surface of the cross-linked polydimethylsiloxane (PDMS) substrate was realized by employing a simple swelling-deswelling process of PDMS substrate in a block-type polymer solution with the aim of development of a temporal cell adhesive substrate. The ABA block-type polymer composed of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) segment and PDMS segment with over 70% of dimethylsiloxane unit composition could be successfully incorporated in the PDMS substrate during the swelling-deswelling process to prepare the PDMS/phospholipid block copolymer hybrid substrates. During the aging process of the PDMS substrate for 4 days in aqueous medium, its surface property changed gradually from hydrophobic to hydrophilic. X-ray photoelectron spectroscopy and atomic force microscopy data provided strong evidence that the time-dependent hydrophilic conversion of the PDMS/block-type phospholipid polymer hybrid substrate was induced by the diffusion of the hydrophilic PMPC segment in the block-type polymer to be tethered on the substrate. During the hydrophilic conversion process, surface-adsorbed fibronectin was gradually desorbed from the substrate surface, and this resulted in successful detachment of two-dimensional connected cell crowds.
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