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Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease
- Authors
- Jang, Joo Hee; Lee, Hoyeon; Sharma, Amit; Lee, Sang Min; Lee, Tae Hoon; Kang, Chulhun; Kim, Jong Seung
- Issue Date
- 18-Aug-2016
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.52, no.64, pp.9965 - 9968
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 52
- Number
- 64
- Start Page
- 9965
- End Page
- 9968
- ISSN
- 1359-7345
- Abstract
- An indomethacin-guided drug delivery conjugate (IGDDC) has been designed by utilizing cancer associated elevated HDAC and CTSL activities as consecutive demasking ventures for drug activation. IGDDC exhibited preferential uptake by COX-2 positive cells both in vitro and ex vivo highlighting indomethacin's role in designing new cancer-specific drug delivery frameworks.
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Related Researcher
- Kim, Jong Seung
- College of Science (Department of Chemistry)