CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7-and IL-15-dependent niches
- Authors
- Jung, Yong Woo; Kim, Hyun Gyung; Perry, Curtis J.; Kaech, Susan M.
- Issue Date
- 19-7월-2016
- Publisher
- NATL ACAD SCIENCES
- Keywords
- CCR7; memory T cell; IL-7; IL-15; homeostasis
- Citation
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.113, no.29, pp.8278 - 8283
- Indexed
- SCIE
SCOPUS
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Volume
- 113
- Number
- 29
- Start Page
- 8278
- End Page
- 8283
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/88048
- DOI
- 10.1073/pnas.1602899113
- ISSN
- 0027-8424
- Abstract
- C-C receptor 7 (CCR7) is important to allow T cells and dendritic cells to migrate toward CCL19- and CCL21-producing cells in the T-cell zone of the spleen and lymph nodes. The role of this chemokine receptor in regulating the homeostasis of effector and memory T cells during acute viral infection is poorly defined, however. In this study, we show that CCR7 expression alters memory CD8 T-cell homeostasis following lymphocytic choriomeningitis virus infection. Greater numbers of CCR7-deficient memory T cells were formed and maintained compared with CCR7-sufficient memory T cells, especially in the lung and bone marrow. The CCR7-deficient memory T cells also displayed enhanced rates of homeostatic turnover, which may stem from increased exposure to IL-15 as a consequence of reduced exposure to IL-7, because removal of IL-15, but not of IL-7, normalized the numbers of CCR7-sufficient and CCR7-deficient memory CD8 T cells. This result suggests that IL-15 is the predominant cytokine supporting augmentation of the CCR7(-/-) memory CD8 T-cell pool. Taken together, these data suggest that CCR7 biases memory CD8 T cells toward IL-7-dependent niches over IL-15-dependent niches, which provides insight into the homeostatic regulation of different memory T-cell subsets.
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