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Cinnamomum loureirii Extract Inhibits Acetylcholinesterase Activity and Ameliorates Trimethyltin-Induced Cognitive Dysfunction in Mice

Authors
Kim, Cho RongChoi, Soo JungKwon, Yoon KyungKim, Jae KyeomKim, Youn-JungPark, Gwi GunShin, Dong-Hoon
Issue Date
7월-2016
Publisher
PHARMACEUTICAL SOC JAPAN
Keywords
Alzheimer' s disease; Cinnamomum loureirii; acetylcholine; acetylcholinesterase inhibitor
Citation
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.39, no.7, pp.1130 - 1136
Indexed
SCIE
SCOPUS
Journal Title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume
39
Number
7
Start Page
1130
End Page
1136
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/88276
DOI
10.1248/bpb.b16-00045
ISSN
0918-6158
Abstract
The pathogenesis of Alzheimer's disease (AD) has been linked to the deficiency of neurotransmitter acetylcholine (ACh) in the brain, and the main treatment strategy for improving AD symptoms is the inhibition of acetylcholinesterase (AChE) activity. In the present study, we aimed to identify potent AChE inhibitors from Cinnamomum loureirii extract via bioassay-guided fractionation. We demonstrated that the most potent AChE inhibitor present in the C. loureirii extract was 2,4-bis(1,1-dimethylethyl)phenol. To confirm the antiamnesic effects of the ethanol extract of C. loureirii, mice were intraperitoneally injected with the neurotoxin trimethyltin (2.5mg/kg) to induce cognitive dysfunction, and performance in the Y-maze and passive avoidance tests was assessed. Treatment with C. loureirii extract significantly improved performance in both behavioral tests, suggesting that this extract may be neuroprotective and therefore beneficial in preventing or ameliorating the degenerative processes of AD, potentially by restoring cholinergic function.
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