Induction of tolerance against the arthritogenic antigen with type-II collagen peptide-linked soluble MHC class II molecules
- Authors
- Park, Yoon-Kyung; Jung, Sundo; Park, Se-Ho
- Issue Date
- 30-6월-2016
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Keywords
- Collagen-induced arthritis; Immunotherapy; Rheumatoid arthriti; Recombinant MHC II; Type-II collagen
- Citation
- BMB REPORTS, v.49, no.6, pp.331 - 336
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BMB REPORTS
- Volume
- 49
- Number
- 6
- Start Page
- 331
- End Page
- 336
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/88293
- DOI
- 10.5483/BMBRep.2016.49.6.207
- ISSN
- 1976-6696
- Abstract
- In murine collagen-induced arthritis (CIA), self-reactive T cells can recognize peptide antigens derived from type-II collagen (CII). Activation of T cells is an important mediator of autoimmune diseases. Thus, T cells have become a focal point of study to treat autoimmune diseases. In this study, we evaluated the efficacy of recombinant MHC class II molecules in the regulation of antigen-specific T cells by using a self peptide derived from CII (CII260-274; IAGFKGEQGPKGEPG) linked to mouse I-A(q) in a murine CIA model. We found that recombinant I-A(q)/CII260-274 molecules could be recognized by CII-specific T cells and inhibit the same T cells in vitro. Furthermore, the development of CIA in mice was successfully prevented by in vivo injection of recombinant I-A(q)/CII260-274 molecules. Thus, treatment with recombinant soluble MHC class II molecules in complex with an immunodominant self-peptide might offer a potential therapeutic for chronic inflammation in autoimmune disease such as rheumatoid arthritis.
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