Dermatologic evaluation of cosmetic formulations containing Chrysanthemum indicum extract
DC Field | Value | Language |
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dc.contributor.author | Choi, Keun Taek | - |
dc.contributor.author | Kim, Jun Ho | - |
dc.contributor.author | Cho, Hyung Taek | - |
dc.contributor.author | Lim, Soon Sung | - |
dc.contributor.author | Kwak, Sun Soon | - |
dc.contributor.author | Kim, Young Jun | - |
dc.date.accessioned | 2021-09-03T23:13:49Z | - |
dc.date.available | 2021-09-03T23:13:49Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-06 | - |
dc.identifier.issn | 1473-2130 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/88432 | - |
dc.description.abstract | BackgroundChrysanthemum indicum, an oriental medicinal plant, has been shown to display a variety of pharmacological activities including antibacterial and anti-inflammatory effects. AimsIn this study, we evaluated the ability of C. indicum extracts to inhibit in vitro tyrosinase activity and the skin care effects of cosmetic formulations containing 0.5% C. indicum water extract in human volunteers. Patients/MethodsThe formation of dopachrome from (L)-dopa by mushroom tyrosinase was observed after treatments with C. indicum extracts. The volunteers received placebo (no extract) or test (0.5% C. indicum water extract) cosmetic cream and applied it on their face three times a day for 6 weeks. Biophysical skin parameters were measured every 2 weeks. ResultsChrysanthemum indicum methanol and water extracts dose dependently inhibited mushroom tyrosinase activity, and the effects of methanol extract were similar to those of kojic acid, a well-known tyrosinase inhibitor. Clinical evaluations revealed that application of cosmetic formulations containing C. indicum water extract time dependently reduced melanin levels over 6 weeks, whereas the placebo group showed no effect. No changes in moisture, elasticity, wrinkles, evenness, and pore size were observed in either group. HPLC-DAD-ESIMS analyses revealed that luteolin and acacetin-7-O-rutinoside are the major flavonoid compounds in C. indicum water extract. ConclusionThese results suggest that C. indicum water extract could be applied as a natural skin-whitening agent for functional cosmetic uses, due to its melanin-reducing efficacy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | CONTROLLED-TRIAL | - |
dc.subject | ANTI-TYROSINASE | - |
dc.subject | FLAVONOIDS | - |
dc.subject | SKIN | - |
dc.subject | MELANOGENESIS | - |
dc.subject | RADIATION | - |
dc.title | Dermatologic evaluation of cosmetic formulations containing Chrysanthemum indicum extract | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jun Ho | - |
dc.contributor.affiliatedAuthor | Kim, Young Jun | - |
dc.identifier.doi | 10.1111/jocd.12211 | - |
dc.identifier.scopusid | 2-s2.0-84975076454 | - |
dc.identifier.wosid | 000379017300009 | - |
dc.identifier.bibliographicCitation | JOURNAL OF COSMETIC DERMATOLOGY, v.15, no.2, pp.162 - 168 | - |
dc.relation.isPartOf | JOURNAL OF COSMETIC DERMATOLOGY | - |
dc.citation.title | JOURNAL OF COSMETIC DERMATOLOGY | - |
dc.citation.volume | 15 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 162 | - |
dc.citation.endPage | 168 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | ANTI-TYROSINASE | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | MELANOGENESIS | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordAuthor | Chrysanthemum indicum | - |
dc.subject.keywordAuthor | tyrosinase | - |
dc.subject.keywordAuthor | cosmetic formulation | - |
dc.subject.keywordAuthor | melanogenesis | - |
dc.subject.keywordAuthor | skin physiology | - |
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