Anti-inflammatory action of ethanolic extract of Ramulus mori on the BLT2-linked cascade
- Authors
- Park, Geun-Soo; Kim, Jeong-Keun; Kim, Jae-Hong
- Issue Date
- 4월-2016
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Keywords
- BLT2; IL-6; Ramulus mori; Raw264.7 cells; ROS
- Citation
- BMB REPORTS, v.49, no.4, pp.232 - 237
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BMB REPORTS
- Volume
- 49
- Number
- 4
- Start Page
- 232
- End Page
- 237
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/89024
- DOI
- 10.5483/BMBRep.2016.49.4.002
- ISSN
- 1976-6696
- Abstract
- Mulberry tree twigs (Ramulus mori) contain large amounts of oxyresveratrols and have traditionally been used as herbal medicines because of their anti-inflammatory properties. However, the signaling mechanism by which R. mori exerts its anti-inflammatory action remains to be elucidated. In this study, we observed that R. mori ethanol extracts (RME) exerted an inhibitory effect on the lipopolysaccharide (LPS)-induced production of the pro-inflammatory cytokine interleukin-6 (IL-6) in Raw264.7 macrophage cells. Additionally, RME inhibited IL-6 production by blocking the leukotriene B-4 receptor-2 (BLT2)-dependent-NADPH oxidase 1 (NOX1)-reactive oxygen species (ROS) cascade, leading to anti-inflammatory activity. Finally, RME suppressed the production of the BLT2 ligands LTB4 and 12(S)-HETE by inhibiting the p38 kinase-cytosolic phospholipase A(2)-5-/12-lipoxygenase cascade in LPS-stimulated Raw264.7 cells. Overall, our results suggest that RME inhibits the 'BLT2 ligand-BLT2'-linked autocrine inflammatory axis, and that this BLT2-linked cascade is one of the targets of the anti-inflammatory action of R. mori.
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