Efficacy of postoperative mitomycin-C eye drops on the clinical outcome in endoscopic dacryocystorhinostomy
- Authors
- Do, Jae Rock; Lee, Hwa; Baek, Sehyun; Lee, Tae Soo; Chang, Minwook
- Issue Date
- 4월-2016
- Publisher
- SPRINGER
- Keywords
- Dacryocystorhinostomy; Endoscopy; Mitomycin; Nasolacrimal duct
- Citation
- GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, v.254, no.4, pp.785 - 790
- Indexed
- SCIE
SCOPUS
- Journal Title
- GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
- Volume
- 254
- Number
- 4
- Start Page
- 785
- End Page
- 790
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/89063
- DOI
- 10.1007/s00417-015-3229-2
- ISSN
- 0721-832X
- Abstract
- To evaluate the effect of postoperative topical mitomycin-C (MMC) eye drops in endoscopic (dacryocystorhinostomy) DCR and compare them with intraoperative MMC soaking. Retrospective, nonrandomized, interventional case series. One hundred and sixty cases of endoscopic DCR with a single surgeon for primary nasolacrimal duct obstruction (NLDO) were included. Cases were divided into three groups. Group 1 was treated with intraoperative application of 0.02 % MMC for 5 min. Group 2 was treated with 0.02 % MMC eye drops for 5 days after surgery, without intraoperative application of MMC. Group 3 was the control group of cases without the use of MMC. Each group was evaluated for surgical success, presence of complications including granuloma, synechiae, and tube-induced inflammation, and the adverse effect of the MMC at least 6 months after the surgery. The success rate showed no significant difference among the three groups (P = .122, chi-square analysis). In the analysis between the two groups, although the success rate of Group 2 appeared not to be statistically different compared with that of Group 1 (P = .419, chi-square analysis), Group 2 had a statistically higher success rate for surgery than Group 3 (P = .041, chi-square analysis). The presence of granuloma was significantly lower in Group 1 than in the other two groups (P = .022, chi-square analysis). Synechiae and silicone tube-induced inflammation were not significantly different (P = .308, P = .881, chi-square analysis). There were no adverse effects associated with intraoperative or postoperative MMC application. Use of postoperative topical 0.02 % MMC is a safe and effective adjunctive modality to increase the success rate of endoscopic DCR.
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