The Effect of Nefopam on Postoperative Fentanyl Consumption: A Randomized, Double-blind Study
- Authors
- Moon, Jee Youn; Choi, Sang Sik; Lee, Shin Young; Lee, Mi Kyung; Kim, Jung Eun; Lee, Ji Eun; Lee, So Hyun
- Issue Date
- 4월-2016
- Publisher
- KOREAN PAIN SOC
- Keywords
- Deep sedation; Double blind study; Hysterectomy; Nefopam; Opioids; Pain measurement; Patient-controlled analgesia; Postoperative pain
- Citation
- KOREAN JOURNAL OF PAIN, v.29, no.2, pp.110 - 118
- Indexed
- SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF PAIN
- Volume
- 29
- Number
- 2
- Start Page
- 110
- End Page
- 118
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/89104
- DOI
- 10.3344/kjp.2016.29.2.110
- ISSN
- 2005-9159
- Abstract
- Background: Nefopam is a non-opioid, non-steroidal, centrally acting analgesic drug. The concomitant use of opioids and nefopam is believed to have many advantages over the administration of opioids alone for postoperative pain management. We conducted a randomized, double-blind study to determine the fentanyl-sparing effect of co-administration of nefopam with fentanyl for postoperative pain management via patient controlled analgesia (PCA). Methods: Ninety female patients who underwent laparoscopic total hysterectomy under general anesthesia were randomized into 3 groups, Group A, fentanyl 1,000 mu g; Group B, fentanyl 500 mu g + nefopam 200 mg; and Group C, fentanyl 500 mu g + nefopam 400 mg, in a total volume of 100 ml PCA to be administered over the first 48 h postoperatively without basal infusion. The primary outcome was total fentanyl consumption during 48 h; secondary outcomes included pain scores and incidence of side effects. Results: Eighty-one patients were included in the analysis. The overall fentanyl-sparing effects of PCA with concomitant administration of nefopam during the first 48 h postoperatively were 54.5% in Group B and 48.9% group C. Fentanyl use was not significantly different between Groups B and C despite the difference in the nefopam dose. There were no differences among the three groups in terms of PCA-related side effects, although the overall sedation score of Group B was significantly lower than that of Group A. Conclusions: The concomitant administration of nefopam with fentanyl for postoperative pain management may allow reduction of fentanyl dose, thereby reducing the risk of opioid-related adverse effects.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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