Effects of Cyclo-His-Pro-enriched yeast hydrolysate on blood glucose levels and lipid metabolism in obese diabetic ob/ob mice
DC Field | Value | Language |
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dc.contributor.author | Jung, Eun Young | - |
dc.contributor.author | Hong, Yang Hee | - |
dc.contributor.author | Park, Chung | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2021-09-04T01:16:43Z | - |
dc.date.available | 2021-09-04T01:16:43Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 1976-1457 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89157 | - |
dc.description.abstract | BACKGROUND/OBJECTIVE: We examined the hypoglycemic and anti-hyperlipidemic effect of yeast hydrolysate (YH) enriched with Cyclo-His-Pro (CHP) in the C57BL/6J ob/ob mouse model. MATERIALS/METHODS: Mice were separated into 4 groups (8 mice/group) on the basis of blood glucose and body weight: WT control, lean mice given vehicle; ob/ob control, ob/ob mice given vehicle; YH-1, ob/ob mice given 0.5 g/kg of YH; YH-2, ob/ob mice given 1 g/kg of YH. YH in saline or vehicle was administered orally in the same volume every day for 3 weeks. RESULTS: Mice treated with YH (0.5 and 1 g/kg) for 3 weeks displayed a significant reduction in overall body weight gain and perirenal and epididymal adipose tissue weight compared to the ob/ob control group. Additionally, high-density lipoprotein (HDL) cholesterol, glucose, and atherogenic indexes were significantly decreased in the blood of YH-1 and YH-2 groups compared to the ob/ob control. In ob/ob mice, YH administration significantly improved glucose tolerance and blood insulin levels. These data indicate that YH treatment produces potent hypoglycemic and anti-hyperlipidemic effects by controlling body weight, fat mass, blood lipid, insulin levels, and glucose tolerance. CONCLUSION: YH could potentially be used as a treatment option for diabetes and hyperlipidemia. The CHP-enriched YH may be a promising strategy in the development of hypoglycemic peptide nutraceuticals. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN NUTRITION SOC | - |
dc.subject | ARACHIDONIC-ACID | - |
dc.subject | ORGAN WEIGHTS | - |
dc.subject | FOOD-INTAKE | - |
dc.subject | RATS | - |
dc.subject | ZINC | - |
dc.subject | MELLITUS | - |
dc.subject | TRANSPORT | - |
dc.subject | DISEASE | - |
dc.subject | IMMUNOREACTIVITY | - |
dc.subject | COMPLICATIONS | - |
dc.title | Effects of Cyclo-His-Pro-enriched yeast hydrolysate on blood glucose levels and lipid metabolism in obese diabetic ob/ob mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.4162/nrp.2016.10.2.154 | - |
dc.identifier.scopusid | 2-s2.0-84963719262 | - |
dc.identifier.wosid | 000373553000004 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH AND PRACTICE, v.10, no.2, pp.154 - 160 | - |
dc.relation.isPartOf | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.title | NUTRITION RESEARCH AND PRACTICE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 154 | - |
dc.citation.endPage | 160 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002096108 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | ARACHIDONIC-ACID | - |
dc.subject.keywordPlus | ORGAN WEIGHTS | - |
dc.subject.keywordPlus | FOOD-INTAKE | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | ZINC | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | IMMUNOREACTIVITY | - |
dc.subject.keywordPlus | COMPLICATIONS | - |
dc.subject.keywordAuthor | Yeast hydrolysate | - |
dc.subject.keywordAuthor | blood glucose | - |
dc.subject.keywordAuthor | diabetes mellitus | - |
dc.subject.keywordAuthor | cyclo-his-pro | - |
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