Effects of Cyclo-His-Pro-enriched yeast hydrolysate on blood glucose levels and lipid metabolism in obese diabetic ob/ob mice
- Authors
- Jung, Eun Young; Hong, Yang Hee; Park, Chung; Suh, Hyung Joo
- Issue Date
- 4월-2016
- Publisher
- KOREAN NUTRITION SOC
- Keywords
- Yeast hydrolysate; blood glucose; diabetes mellitus; cyclo-his-pro
- Citation
- NUTRITION RESEARCH AND PRACTICE, v.10, no.2, pp.154 - 160
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- NUTRITION RESEARCH AND PRACTICE
- Volume
- 10
- Number
- 2
- Start Page
- 154
- End Page
- 160
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/89157
- DOI
- 10.4162/nrp.2016.10.2.154
- ISSN
- 1976-1457
- Abstract
- BACKGROUND/OBJECTIVE: We examined the hypoglycemic and anti-hyperlipidemic effect of yeast hydrolysate (YH) enriched with Cyclo-His-Pro (CHP) in the C57BL/6J ob/ob mouse model. MATERIALS/METHODS: Mice were separated into 4 groups (8 mice/group) on the basis of blood glucose and body weight: WT control, lean mice given vehicle; ob/ob control, ob/ob mice given vehicle; YH-1, ob/ob mice given 0.5 g/kg of YH; YH-2, ob/ob mice given 1 g/kg of YH. YH in saline or vehicle was administered orally in the same volume every day for 3 weeks. RESULTS: Mice treated with YH (0.5 and 1 g/kg) for 3 weeks displayed a significant reduction in overall body weight gain and perirenal and epididymal adipose tissue weight compared to the ob/ob control group. Additionally, high-density lipoprotein (HDL) cholesterol, glucose, and atherogenic indexes were significantly decreased in the blood of YH-1 and YH-2 groups compared to the ob/ob control. In ob/ob mice, YH administration significantly improved glucose tolerance and blood insulin levels. These data indicate that YH treatment produces potent hypoglycemic and anti-hyperlipidemic effects by controlling body weight, fat mass, blood lipid, insulin levels, and glucose tolerance. CONCLUSION: YH could potentially be used as a treatment option for diabetes and hyperlipidemia. The CHP-enriched YH may be a promising strategy in the development of hypoglycemic peptide nutraceuticals.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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