Correlation between Semi-Quantitative F-18-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer
- Authors
- Park, Soyeon; Lee, Eunsub; Rhee, Seunghong; Cho, Jaehyuk; Choi, Sunju; Lee, Sinae; Eo, Jae Seon; Pahk, Kisoo; Choe, Jae Gol; Kim, Sungeun
- Issue Date
- 3월-2016
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- Small-cell lung carcinoma; F-18-FDG PET/CT; Metabolic tumor volume; Ki-67
- Citation
- NUCLEAR MEDICINE AND MOLECULAR IMAGING, v.50, no.1, pp.24 - 30
- Indexed
- SCOPUS
KCI
- Journal Title
- NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Volume
- 50
- Number
- 1
- Start Page
- 24
- End Page
- 30
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/89348
- DOI
- 10.1007/s13139-015-0363-z
- ISSN
- 1869-3474
- Abstract
- Purpose The aimof this study was to evaluate the relationship between semiquantitative parameters on F-18-FDG PET/CT including maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and the expression level of Ki-67 in small-cell lung cancer (SCLC). Methods Ninety-four consecutive patients with SCLC were enrolled in this study. They underwent F-18-FDG PET/CT for initial evaluation of SCLC, and we measured SUVmax, avgSUVmean, MTVsum, and TLGtotal on F-18-FDG PET/CT images. The protein expression of Ki-67 was examined by immunohistochemical staining. Results Significant correlations were found between the MTVsum and Ki-67 labeling index (r=0.254, p=0.014) and the TLGtotal and Ki-67 labeling index (r=0.239, p=0.020). No correlation was found between the SUVmax and Ki-67 labeling index (r=0.116, p=0.264) and the avgSUVmean and Ki-67 labeling index (r=0.031, p=0.770). Dividing the Ki-67 expression level into three categories, it was suggested that increasing Ki-67 expression level caused a stepwise increase in the MTVsum and TLGtotal. (p=0.028 and 0.039, respectively), but not the SUVmax and avgSUVmean (p=0.526 and 0.729, respectively). Conclusion In conclusion, the volume-based parameters of F-18-FDG PET/CT correlate with immunohistochemical staining of Ki-67 in SCLC. Measurement of the MTVsum and TLGtotal by F-18-FDG PET/CT might be a simple, non-invasive, and useful method to determine the proliferative potential of cancer cells.
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