The effects of Chamaecyparis obtusa essential oil on pain-related behavior and expression of pro-inflammatory cytokines in carrageenan-induced arthritis in rats
- Authors
- Suh, Hye Rim; Chung, Hyun Joo; Park, Eui Ho; Moon, Sun Wook; Park, Su Jin; Park, Chan Woo; Kim, Yang In; Han, Hee Chul
- Issue Date
- 2-1월-2016
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Chamaecyparis obtusa essential oil; carrageenan-induced arthritis; pro-inflammatory cytokines; dynamic weight load
- Citation
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.80, no.1, pp.203 - 209
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Volume
- 80
- Number
- 1
- Start Page
- 203
- End Page
- 209
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/89852
- DOI
- 10.1080/09168451.2015.1075864
- ISSN
- 0916-8451
- Abstract
- Chamaecyparis obtusa essential oil (COE) has been widely used to treat allergic diseases and was suggested to exert anti-inflammatory, antioxidant, and antimicrobial effects. This study evaluated the effects of COE on pain-related behavior and pro-inflammatory cytokines in rats with carrageenan (CGN)-induced arthritis. Reduced dynamic weight load on inflamed joint in voluntarily walking rats was used as the behavior test for arthritic pain; 10% COE-treated group was significantly attenuated pain (6-8h post-CGN injection) compared to VEH (mineral oil)-treated group. In addition, the protein levels of interleukin (IL)-1, tumor necrosis factor-, IL-6 (6-8h), and cyclooxygenase (COX)-2 (8h) within the synovial membrane, as well as IL-1, COX-2 (6-8h), and IL-6 (5-7h) within the meniscus, of 10% COE-treated group were significantly reduced. The current results implicate that COE has anti-inflammatory and anti-nociceptive effects on arthritis in rats.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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