Pheophorbide a from Capsosiphon fulvescens Inhibits Advanced Glycation End Products Mediated Endothelial Dysfunction
DC Field | Value | Language |
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dc.contributor.author | Hong, Chung-Oui | - |
dc.contributor.author | Nam, Mi-Hyun | - |
dc.contributor.author | Oh, Ji-Sun | - |
dc.contributor.author | Lee, Jin-Won | - |
dc.contributor.author | Kim, Cheong-Tae | - |
dc.contributor.author | Park, Kwon-Woo | - |
dc.contributor.author | Lee, Dong-Ho | - |
dc.contributor.author | Lee, Kwang-Won | - |
dc.date.accessioned | 2021-09-04T04:33:14Z | - |
dc.date.available | 2021-09-04T04:33:14Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/89968 | - |
dc.description.abstract | During hyperglycemia, the first step toward the formation of advanced glycation end products is the nonenzymatic glycation between the carbonyl group of a sugar and the primary amino group of a protein. Advanced glycation end products are then produced through more complex reactions. Reactive oxygen species derived from advanced glycation end products may play a key role in inflammation of the endothelium, leading to the complications seen in diabetes. Glycolaldehyde-induced advanced glycation end products have been reported to express proinflammatory cytokines, such as tumor necrosis factor-a and interleukin-1 beta. This study focused on Capsosiphon fulvescens, a Capsosiphonaceae type of green algae that has shown potential as a functional food material. Pheophorbide a, an anti-glycation compound, was isolated from C. fulvescens by extraction using a mixture of ethanol and water, followed by column fractionation of the resulting extract. The compound separated from C. fulvescens was identified by means of high-performance liquid chromatography combined with mass spectrometry. Pheophorbide a showed scavenging activity of the intracellular reactive oxygen species as well as monocyte adhesiveness inhibitory activity on the human myelomonocytic cell line (THP-1) and human umbilical vein endothelial cells cocultivation system. The mRNA levels of inflammation-related genes such as monocyte chemoattractant protein-1 and interleukin-6 were significantly decreased by pheophorbide a, and advanced glycation end products-stimulated tumor necrosis factor-a and interleukin-1 beta were downregulated as well. These results indicate that pheophorbide a has significant reactive oxygen species-scavenging activity, monocyte adhesive inhibitory activity, and downregulatory activity of cytokines related to inflammation affecting the endothelium. Pheophorbide a could therefore be a promising candidate for modulating endothelial cell dysfunction. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.subject | TERMINALIA-CHEBULA | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | AGE INHIBITORS | - |
dc.subject | ENDPRODUCTS | - |
dc.subject | ASSAY | - |
dc.subject | ATHEROSCLEROSIS | - |
dc.subject | PROLIFERATION | - |
dc.subject | INFLAMMATION | - |
dc.subject | MECHANISMS | - |
dc.subject | MONOCYTES | - |
dc.title | Pheophorbide a from Capsosiphon fulvescens Inhibits Advanced Glycation End Products Mediated Endothelial Dysfunction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dong-Ho | - |
dc.contributor.affiliatedAuthor | Lee, Kwang-Won | - |
dc.identifier.doi | 10.1055/s-0035-1557829 | - |
dc.identifier.scopusid | 2-s2.0-84954179550 | - |
dc.identifier.wosid | 000368084700005 | - |
dc.identifier.bibliographicCitation | PLANTA MEDICA, v.82, no.1-2, pp.46 - 57 | - |
dc.relation.isPartOf | PLANTA MEDICA | - |
dc.citation.title | PLANTA MEDICA | - |
dc.citation.volume | 82 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 46 | - |
dc.citation.endPage | 57 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | TERMINALIA-CHEBULA | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | AGE INHIBITORS | - |
dc.subject.keywordPlus | ENDPRODUCTS | - |
dc.subject.keywordPlus | ASSAY | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | MONOCYTES | - |
dc.subject.keywordAuthor | Capsosiphon fulvescens | - |
dc.subject.keywordAuthor | Capsosiphonaceae | - |
dc.subject.keywordAuthor | pheophorbide a | - |
dc.subject.keywordAuthor | advanced glycation end product | - |
dc.subject.keywordAuthor | proinflammatory cytokine | - |
dc.subject.keywordAuthor | endothelial cell dysfunction | - |
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