Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells
- Authors
- Jang, Hari; Lee, Jin Woo; Lee, Chul; Jin, Qinghao; Choi, Jeong Yeon; Lee, Dongho; Han, Sang Bae; Kim, Youngsoo; Hong, Jin Tae; Lee, Mi Kyeong; Hwang, Bang Yeon
- Issue Date
- Jan-2016
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Tussilago farfara; Asteraceae; Oplopane-type; sesquiterpenoid; Nitric oxide production inhibitor
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.39, no.1, pp.127 - 132
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 39
- Number
- 1
- Start Page
- 127
- End Page
- 132
- ISSN
- 0253-6269
- Abstract
- A new oplopane-type sesquiterpenoid tussilagofarin (1) and a new chromone tussilagofarol (2), along with 18 known compounds 3-20, were isolated from the flower buds of Tussilago farfara. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and HRESIMS data. Of the isolated compounds, oplopane- and bisabolane-type sesquterpenoids 1, 8-12, 15, and 16 were found to inhibit nitric oxide production in LPS-induced RAW 264.7 cells with IC50 values of 3.5-28.5 mu M.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology