Topical application of spent coffee ground extracts protects skin from ultraviolet B-induced photoaging in hairless mice
DC Field | Value | Language |
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dc.contributor.author | Choi, Hyeon-Son | - |
dc.contributor.author | Park, Eu Ddeum | - |
dc.contributor.author | Park, Yooheon | - |
dc.contributor.author | Han, Sung Hee | - |
dc.contributor.author | Hong, Ki Bae | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2021-09-04T05:01:53Z | - |
dc.date.available | 2021-09-04T05:01:53Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1474-905X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/90157 | - |
dc.description.abstract | The aim of this study was to evaluate the protective effect of spent coffee ground (SCG) on ultraviolet (UV) B-induced photoaging in hairless mice. The oil fraction (OSCG) and ethanol extract (ESCG) of SCG were prepared from SCG. OSCG contained a much higher level of caffeine (547.32 +/- 1.68 mu g mg(-1)) when compared to the sum of its chlorogenic acid derivatives (similar to 119 mu g mg(-1)), and pyrazines were the major aromatic compounds in OSCG. OSCG effectively inhibited the UVB-induced increase in intracellular reactive oxygen species in HaCaT cells. Topical application of OSCG or ESCG significantly reduced the UVB-induced wrinkle formation in mice dorsal skin. The combined application of OSCG and ESCG (OEH) led to a decrease in the wrinkle area by over 35% when compared with the UVB-treated control (UVBC). Epidermal thickness was also reduced by 40%. This result was connected to the significant reduction in transdermal water loss (27%) and erythema formation (48%) that result from UVB irradiation. Polarizationsensitive optical coherence tomography (PS-OCT) and antibody-based histological analyses showed that OSCG and ESCG effectively suppressed the UVB-induced decrease in collagen content. The level of type 1 collagen (COL1) in the OEH group was enhanced by around 40% compared with the UVB control group (UVBC). This was attributed to the down-regulation of matrix metalloproteinases (MMP2, 9, and 13), which are known to be responsible for collagen destruction. Our results indicate that topical treatment with OSCG/ESCG protects mouse skin from UVB-induced photoaging by down-regulating MMPs; therefore, suggesting the potential of SCG extracts as a topical anti-photoaging agent. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | GREEN TEA | - |
dc.subject | UV-LIGHT | - |
dc.subject | EXPRESSION | - |
dc.subject | ACID | - |
dc.subject | MECHANISMS | - |
dc.subject | CAFFEINE | - |
dc.subject | CAFESTOL | - |
dc.subject | STRAINS | - |
dc.subject | KAHWEOL | - |
dc.title | Topical application of spent coffee ground extracts protects skin from ultraviolet B-induced photoaging in hairless mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1039/c6pp00045b | - |
dc.identifier.scopusid | 2-s2.0-84973861183 | - |
dc.identifier.wosid | 000378514600008 | - |
dc.identifier.bibliographicCitation | PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, v.15, no.6, pp.779 - 790 | - |
dc.relation.isPartOf | PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | - |
dc.citation.title | PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | - |
dc.citation.volume | 15 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 779 | - |
dc.citation.endPage | 790 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | GREEN TEA | - |
dc.subject.keywordPlus | UV-LIGHT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | CAFFEINE | - |
dc.subject.keywordPlus | CAFESTOL | - |
dc.subject.keywordPlus | STRAINS | - |
dc.subject.keywordPlus | KAHWEOL | - |
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