Dietary Nanosized Lactobacillus plantarum Enhances the Anticancer Effect of Kimchi on Azoxymethane and Dextran Sulfate Sodium-Induced Colon Cancer in C57BL/6J Mice
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun Ah | - |
dc.contributor.author | Kim, Hyunung | - |
dc.contributor.author | Lee, Kwang-Won | - |
dc.contributor.author | Park, Kun-Young | - |
dc.date.accessioned | 2021-09-04T05:04:37Z | - |
dc.date.available | 2021-09-04T05:04:37Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0731-8898 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/90177 | - |
dc.description.abstract | This study was undertaken to evaluate enhancement of the chemopreventive properties of kimchi by dietary nanosized Lactobacillus (Lab.) plantarum (nLp) in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis-associated colorectal cancer C57BL/6J mouse model. nLp is a dead, shrunken, processed form of Lab. plantarum isolated from kimchi that is 0.5-1.0 mu m in size. The results obtained showed that animals fed kimchi with nLp (K-nLp) had longer colons and lower colon weights/length ratios and developed fewer tumors than mice fed kimchi alone (K). In addition, K-nLp administration reduced levels of proinflammatory cytokine serum levels and mediated the mRNA and protein expressions of inflammatory, apoptotic, and cell-cycle markers to suppress inflammation and induce tumor-cell apoptosis and cell-cycle arrest. Moreover, it elevated natural killer-cell cytotoxicity. The study suggests adding nLp to kimchi could improve the suppressive effect of kimchi on AOM/DSS-induced colorectal cancer. These findings indicate nLp has potential use as a functional chemopreventive ingredient in the food industry. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BEGELL HOUSE INC | - |
dc.subject | CELL-CYCLE | - |
dc.subject | COLITIS | - |
dc.subject | COX-2 | - |
dc.subject | CARCINOGENESIS | - |
dc.subject | PROLIFERATION | - |
dc.subject | CYTOTOXICITY | - |
dc.subject | APOPTOSIS | - |
dc.subject | INOS | - |
dc.subject | BAX | - |
dc.title | Dietary Nanosized Lactobacillus plantarum Enhances the Anticancer Effect of Kimchi on Azoxymethane and Dextran Sulfate Sodium-Induced Colon Cancer in C57BL/6J Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kwang-Won | - |
dc.identifier.doi | 10.1615/JEnvironPatholToxicolOncol.2016015633 | - |
dc.identifier.scopusid | 2-s2.0-84979934323 | - |
dc.identifier.wosid | 000380779200005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY, v.35, no.2, pp.147 - 159 | - |
dc.relation.isPartOf | JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY | - |
dc.citation.title | JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY | - |
dc.citation.volume | 35 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 147 | - |
dc.citation.endPage | 159 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | CELL-CYCLE | - |
dc.subject.keywordPlus | COLITIS | - |
dc.subject.keywordPlus | COX-2 | - |
dc.subject.keywordPlus | CARCINOGENESIS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | INOS | - |
dc.subject.keywordPlus | BAX | - |
dc.subject.keywordAuthor | dietary nanosized Lactobacillus plantarum | - |
dc.subject.keywordAuthor | kimchi | - |
dc.subject.keywordAuthor | colitis-associated colorectal cancer | - |
dc.subject.keywordAuthor | C57BL/6J mouse | - |
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