Dietary Nanosized Lactobacillus plantarum Enhances the Anticancer Effect of Kimchi on Azoxymethane and Dextran Sulfate Sodium-Induced Colon Cancer in C57BL/6J Mice
- Authors
- Lee, Hyun Ah; Kim, Hyunung; Lee, Kwang-Won; Park, Kun-Young
- Issue Date
- 2016
- Publisher
- BEGELL HOUSE INC
- Keywords
- dietary nanosized Lactobacillus plantarum; kimchi; colitis-associated colorectal cancer; C57BL/6J mouse
- Citation
- JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY, v.35, no.2, pp.147 - 159
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY
- Volume
- 35
- Number
- 2
- Start Page
- 147
- End Page
- 159
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/90177
- DOI
- 10.1615/JEnvironPatholToxicolOncol.2016015633
- ISSN
- 0731-8898
- Abstract
- This study was undertaken to evaluate enhancement of the chemopreventive properties of kimchi by dietary nanosized Lactobacillus (Lab.) plantarum (nLp) in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis-associated colorectal cancer C57BL/6J mouse model. nLp is a dead, shrunken, processed form of Lab. plantarum isolated from kimchi that is 0.5-1.0 mu m in size. The results obtained showed that animals fed kimchi with nLp (K-nLp) had longer colons and lower colon weights/length ratios and developed fewer tumors than mice fed kimchi alone (K). In addition, K-nLp administration reduced levels of proinflammatory cytokine serum levels and mediated the mRNA and protein expressions of inflammatory, apoptotic, and cell-cycle markers to suppress inflammation and induce tumor-cell apoptosis and cell-cycle arrest. Moreover, it elevated natural killer-cell cytotoxicity. The study suggests adding nLp to kimchi could improve the suppressive effect of kimchi on AOM/DSS-induced colorectal cancer. These findings indicate nLp has potential use as a functional chemopreventive ingredient in the food industry.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.