Gene Expression Profile in Patients with Axial Spondyloarthritis: Meta-analysis of Publicly Accessible Microarray DatasetsGene Expression Profile in Patients with Axial Spondyloarthritis: Meta-analysis of Publicly Accessible Microarray Datasets
- Other Titles
- Gene Expression Profile in Patients with Axial Spondyloarthritis: Meta-analysis of Publicly Accessible Microarray Datasets
- Authors
- 박로빈; 김태환; 지종대
- Issue Date
- 2016
- Publisher
- 대한류마티스학회
- Keywords
- Axial spondyloarthritis; Ankylosing spondylitis; Microarray; Network analysis
- Citation
- 대한류마티스학회지, v.23, no.6, pp.363 - 372
- Indexed
- KCI
- Journal Title
- 대한류마티스학회지
- Volume
- 23
- Number
- 6
- Start Page
- 363
- End Page
- 372
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/90477
- ISSN
- 2093-940X
- Abstract
- Objective. To identify a gene expression signature in axial spondyloarthritis/ankylosing spondylitis (SpA/AS) and genomic pathways likely to be involved in pathogenesis of SpA/AS patients. Methods. Four publicly accessible microarray studies from SpA/AS patients were integrated, and a transcriptomic and network-based meta-analysis was performed. This meta-analysis was compared with a published microarray study in whole blood of AS patients. Results. According to our meta-analysis, 1,798 genes were differentially expressed in the whole blood of SpA/AS patients compared to healthy controls, while 674 genes were differentially expressed in the synovium of SpA/AS patients compared to healthy controls. When the whole blood meta-analysis data was compared with a published microarray study that also analyzed whole blood in SpA/AS patients, pathways involved in Toll-like receptor signaling, osteoclast differentiation, T cell receptor signaling and janus kinase–signal transducer and activator of transcription (Jak-STAT) signaling were often enriched in SpA/AS. On the other hand, eomesodermin, RUNX3, and interleukin- 7 receptor (IL7R) were usually decreased in SpA/AS patients, suggesting that deficiency of these genes contributes to increased IL-17 production in AS. Conclusion. Several common enrichment pathways including Toll-like receptor signaling pathway, osteoclast differentiation, T cell receptor signaling pathway and Jak-STAT signaling pathway were identified in the differentially expressed genes of whole blood and synovium from SpA/AS patients, suggesting that these pathways are involved in the pathogenesis of SpA/AS. (J Rheum Dis 2016;23:363-372)
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