Co-delivery of platelet-derived growth factor (PDGF-BB) and bone morphogenic protein (BMP-2) coated onto heparinized titanium for improving osteoblast function and osteointegration
- Authors
- Kim, Sung Eun; Yun, Young-Pil; Lee, Jae Yong; Shim, June-Sung; Park, Kyeongsoon; Huh, Jung-Bo
- Issue Date
- 12월-2015
- Publisher
- WILEY-BLACKWELL
- Keywords
- titanium implant; PDGF-BB; BMP-2; osteoblast; osteointegration; bone regeneration
- Citation
- JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.9, no.12, pp.E219 - E228
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
- Volume
- 9
- Number
- 12
- Start Page
- E219
- End Page
- E228
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/91774
- DOI
- 10.1002/term.1668
- ISSN
- 1932-6254
- Abstract
- The aim of this study was to improve osteoblast function by delivering two growth factors, PDGF-BB and BMP-2, incorporated onto heparinized titanium (Hep-Ti) substrate. To achieve co-delivery of PDGF-BB and BMP-2, the surface of anodized Ti was immobilized with heparin, and then the two growth factors were coated onto the Hep-Ti surface. Incorporation of the two growth factors onto Hep-Ti was evaluated by SEM and XPS. Incorporated PDGF-BB and BMP-2 were released from the Hep-Ti substrate in a sustained manner. In vitro studies revealed that osteoblasts grown on PDGF-BB-and BMP-2-immobilized Hep-Ti increased ALP activity, calcium deposition, osteocalcin and osteopontin levels as compared to those grown on PDGF-BB alone-or BMP-2 alone-immobilized Hep-Ti. These results suggested that co-delivery of PDGF-BB and BMP-2 using Hep-Ti substrate will be a promising material for the enhancement of osteoblast function and osteointegration. Copyright (C) 2013 John Wiley & Sons, Ltd.
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