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A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and gamma-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment
- Authors
- Lee, Wonhwa; Seo, Junyoung; Kwak, Soyoung; Park, Eun Ji; Na, Dong Hee; Kim, Soyoun; Lee, You Mie; Kim, In-San; Bae, Jong-Sup
- Issue Date
- 11-Nov-2015
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- ferritin; nanoparticles; PC-gla; sepsis; TRAP
- Citation
- ADVANCED MATERIALS, v.27, no.42, pp.6637 - +
- Indexed
- SCIE
SCOPUS
- Journal Title
- ADVANCED MATERIALS
- Volume
- 27
- Number
- 42
- Start Page
- 6637
- End Page
- +
- ISSN
- 0935-9648
- Abstract
- New protein nanocages are designed bearing two functional proteins, gamma-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.
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