Systematic Review and Meta-Analysis of Studies Evaluating Diagnostic Test Accuracy: A Practical Review for Clinical. Researchers-Part II. Statistical. Methods of Meta-Analysis
- Authors
- Lee, Juneyoung; Kim, Kyung Won; Choi, Sang Hyun; Huh, Jimi; Park, Seong Ho
- Issue Date
- Nov-2015
- Publisher
- KOREAN RADIOLOGICAL SOC
- Keywords
- Systematic review; Meta-analysis; Diagnostic test accuracy
- Citation
- KOREAN JOURNAL OF RADIOLOGY, v.16, no.6, pp.1188 - 1196
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF RADIOLOGY
- Volume
- 16
- Number
- 6
- Start Page
- 1188
- End Page
- 1196
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/92024
- DOI
- 10.3348/kjr.2015.16.6.1188
- ISSN
- 1229-6929
- Abstract
- Meta-analysis of diagnostic test accuracy studies differs from the usual meta-analysis of therapeutic/interventional studies in that, it is required to simultaneously analyze a pair of two outcome measures such as sensitivity and specificity, instead of a single outcome. Since sensitivity and specificity are generally inversely correlated and could be affected by a threshold effect, more sophisticated statistical methods are required for the meta-analysis of diagnostic test accuracy. Hierarchical models including the bivariate model and the hierarchical summary receiver operating characteristic model are increasingly being accepted as standard methods for meta-analysis of diagnostic test accuracy studies. We provide a conceptual review of statistical methods currently used and recommended for meta-analysis of diagnostic test accuracy studies. This article could serve as a methodological reference for those who perform systematic review and meta-analysis of diagnostic test accuracy studies.
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