Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats
DC Field | Value | Language |
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dc.contributor.author | Seo, Sangjin | - |
dc.contributor.author | Lee, Mak-Soon | - |
dc.contributor.author | Chang, Eugene | - |
dc.contributor.author | Shin, Yoonjin | - |
dc.contributor.author | Oh, Soojung | - |
dc.contributor.author | Kim, In-Hwan | - |
dc.contributor.author | Kim, Yangha | - |
dc.date.accessioned | 2021-09-04T12:58:50Z | - |
dc.date.available | 2021-09-04T12:58:50Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/92566 | - |
dc.description.abstract | Decreased mitochondrial number and dysfunction in skeletal muscle are associated with obesity and the progression of obesity-associated metabolic disorders. The specific aim of the current study was to investigate the effects of rutin on mitochondrial biogenesis in skeletal muscle of high-fat diet-induced obese rats. Supplementation with rutin reduced body weight and adipose tissue mass, despite equivalent energy intake (p < 0.05). Rutin significantly increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as gene expression related to mitochondrial biogenesis, such as peroxisome proliferator-activated receptor coactivator-1 (PGC-1), nuclear respiratory factor-1 (NRF-1), transcription factor A (Tfam), and nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, sirtulin1 (SIRT1) in skeletal muscle (p < 0.05). Moreover, rutin consumption increased muscle adenosine monophosphate-activated protein kinase (AMPK) activity by 40% (p < 0.05). Taken together, these results suggested at least partial involvement of muscle mitochondria and AMPK activation in the rutin-mediated beneficial effect on obesity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.subject | INDUCED INSULIN-RESISTANCE | - |
dc.subject | HUMAN SKELETAL-MUSCLE | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | ACID OXIDATION | - |
dc.subject | WEIGHT-LOSS | - |
dc.subject | NONALCOHOLIC STEATOHEPATITIS | - |
dc.subject | ANTIOXIDANT PROPERTIES | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | PHYSICAL-ACTIVITY | - |
dc.subject | GLUCOSE-UPTAKE | - |
dc.title | Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, In-Hwan | - |
dc.identifier.doi | 10.3390/nu7095385 | - |
dc.identifier.scopusid | 2-s2.0-84942908152 | - |
dc.identifier.wosid | 000361889400059 | - |
dc.identifier.bibliographicCitation | NUTRIENTS, v.7, no.9, pp.8152 - 8169 | - |
dc.relation.isPartOf | NUTRIENTS | - |
dc.citation.title | NUTRIENTS | - |
dc.citation.volume | 7 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 8152 | - |
dc.citation.endPage | 8169 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | INDUCED INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | HUMAN SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | ACID OXIDATION | - |
dc.subject.keywordPlus | WEIGHT-LOSS | - |
dc.subject.keywordPlus | NONALCOHOLIC STEATOHEPATITIS | - |
dc.subject.keywordPlus | ANTIOXIDANT PROPERTIES | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | PHYSICAL-ACTIVITY | - |
dc.subject.keywordPlus | GLUCOSE-UPTAKE | - |
dc.subject.keywordAuthor | rutin | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | skeletal muscle | - |
dc.subject.keywordAuthor | mitochondria | - |
dc.subject.keywordAuthor | AMPK activity | - |
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