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Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats

Authors
Seo, SangjinLee, Mak-SoonChang, EugeneShin, YoonjinOh, SoojungKim, In-HwanKim, Yangha
Issue Date
9월-2015
Publisher
MDPI AG
Keywords
rutin; obesity; skeletal muscle; mitochondria; AMPK activity
Citation
NUTRIENTS, v.7, no.9, pp.8152 - 8169
Indexed
SCIE
SCOPUS
Journal Title
NUTRIENTS
Volume
7
Number
9
Start Page
8152
End Page
8169
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/92566
DOI
10.3390/nu7095385
ISSN
2072-6643
Abstract
Decreased mitochondrial number and dysfunction in skeletal muscle are associated with obesity and the progression of obesity-associated metabolic disorders. The specific aim of the current study was to investigate the effects of rutin on mitochondrial biogenesis in skeletal muscle of high-fat diet-induced obese rats. Supplementation with rutin reduced body weight and adipose tissue mass, despite equivalent energy intake (p < 0.05). Rutin significantly increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as gene expression related to mitochondrial biogenesis, such as peroxisome proliferator-activated receptor coactivator-1 (PGC-1), nuclear respiratory factor-1 (NRF-1), transcription factor A (Tfam), and nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, sirtulin1 (SIRT1) in skeletal muscle (p < 0.05). Moreover, rutin consumption increased muscle adenosine monophosphate-activated protein kinase (AMPK) activity by 40% (p < 0.05). Taken together, these results suggested at least partial involvement of muscle mitochondria and AMPK activation in the rutin-mediated beneficial effect on obesity.
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Kim, In Hwan
보건과학대학 (바이오시스템의과학부)
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