Enantioselective Synthesis of beta-Arylamines via Chiral Phosphoric Acid-Catalyzed Asymmetric Reductive Amination
- Authors
- Kim, Kyung-Hee; Lee, Chun-Young; Cheon, Cheol-Hong
- Issue Date
- 19-6월-2015
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF ORGANIC CHEMISTRY, v.80, no.12, pp.6367 - 6374
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ORGANIC CHEMISTRY
- Volume
- 80
- Number
- 12
- Start Page
- 6367
- End Page
- 6374
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/93244
- DOI
- 10.1021/acs.joc.5b00812
- ISSN
- 0022-3263
- Abstract
- A new method for the synthesis of chiral beta-aryl amines via chiral phosphoric acid-catalyzed enantioselective reductive amination of benzyl methyl ketone derivatives with Hantzsch ester was developed. Various chiral beta-aryl amines were obtained in high yields and with good to high enantioselectivities. This transformation is applicable to gram-scale reactions, and the catalyst loading can be reduced to 1 mol % without sacrificing any catalytic efficacy. Furthermore, the resulting beta-aryl amine was successfully converted into a tetrahydroisoquinoline compound without any loss of enantioselectivity.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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