The insertion/deletion polymorphism in the angiotensin-converting enzyme and susceptibility to schizophrenia or Parkinson's disease: A meta-analysis
- Authors
- Song, Gwan Gyu; Lee, Young Ho
- Issue Date
- 6월-2015
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Angiotensin-converting enzyme; meta-analysis; polymorphism; schizophrenia; Parkinson' s disease
- Citation
- JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, v.16, no.2, pp.434 - 442
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
- Volume
- 16
- Number
- 2
- Start Page
- 434
- End Page
- 442
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/93328
- DOI
- 10.1177/1470320313495909
- ISSN
- 1470-3203
- Abstract
- Introduction: The purpose of this study was to examine whether the insertion (I) and deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) confers susceptibility to schizophrenia and Parkinson's disease (PD). Materials and methods: A meta-analysis was performed of the associations between the ACE I/D polymorphism and schizophrenia and PD. Results: Thirteen studies with 2024 cases and 2230 controls comprising eight studies on schizophrenia and five on PD were included in the meta-analysis. The meta-analysis revealed no association between the ACE D allele and schizophrenia (OR = 0.990, 95% CI = 0.889-1.102, p = 0.856) or PD (OR = 1.067, 95% CI = 0.907-1.255, p = 0.433). Stratification by ethnicity indicated no association between the ACE D allele and schizophrenia in European, Asian, or Turkish ethnic groups (OR = 0.896, 95% CI = 0.566-1.419, p = 0.640; OR = 1.057, 95% CI = 0.903-1.238, p = 0.492; OR = 1.111, 95% CI = 0.889-1.389, p = 0.354, respectively). Ethnicity-specific meta-analysis was not conducted for PD because only one ethnic PD study was available. Conclusions: This meta-analysis found no association between the ACE I/D polymorphism and schizophrenia or PD.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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