Long-term effects of ischemic postconditioning on clinical outcomes: 1-year follow-up of the POST randomized trial
- Authors
- Hahn, Joo-Yong; Yu, Cheol Woong; Park, Hun Sik; Song, Young Bin; Kim, Eun Kyoung; Lee, Hyun Jong; Bae, Jang-Whan; Chung, Woo-Young; Choi, Seung-Hyuk; Choi, Jin-Ho; Bae, Jang-Ho; An, Kyung Joo; Park, Jong-Seon; Oh, Ju Hyeon; Kim, Sang-Wook; Hwang, Jin-Yong; Ryu, Jae Kean; Lim, Do-Sun; Gwon, Hyeon-Cheol
- Issue Date
- May-2015
- Publisher
- MOSBY-ELSEVIER
- Citation
- AMERICAN HEART JOURNAL, v.169, no.5, pp.639 - 646
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN HEART JOURNAL
- Volume
- 169
- Number
- 5
- Start Page
- 639
- End Page
- 646
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/93637
- DOI
- 10.1016/j.ahj.2015.01.015
- ISSN
- 0002-8703
- Abstract
- Background In the Effects of Postconditioning on Myocardial Reperfusion in Patients with ST-segment Elevation Myocardial Infarction (POST) trial, ischemic postconditioning failed to improve myocardial reperfusion. However, long-term effects of ischemic postconditioning on clinical outcomes are not known in patients with ST-segment elevation myocardial infarction. Methods A total of 700 patients undergoing primary percutaneous coronary intervention (PCI) were randomly assigned to the postconditioning group or the conventional primary PCI group in a 1: 1 ratio. Postconditioning was performed immediately after restoration of coronary flow by balloon occlusion 4 times for 1 minute. Complete follow-up data for major clinical events at 1 year were available in 695 patients (99.3%), and analyses were done by the intention to treat principle. The primary outcome was a composite of death, myocardial infarction, severe heart failure, or stent thrombosis at 1 year. Results At 1 year, a composite of death, myocardial infarction, severe heart failure, or stent thrombosis occurred in 21 patients (6.1%) in the postconditioning group and 16 patients (4.6%) in the conventional PCI group (hazard ratio [HR] 1.32, 95% CI 0.69-2.53, P = .40). The risk of death (4.9% vs 3.7%, HR 1.32, 95% CI 0.64-2.71, P = .46), heart failure (2.6% vs 2.3%, HR 1.13, 95% CI 0.44-2.94, P = .80), and stent thrombosis (2.3% vs 1.7%, HR 1.34, 95% CI 0.46-3.85, P = .59) did not differ significantly between the 2 groups. Conclusions Ischemic postconditioning does not seem to improve the 1-year clinical outcomes in patients with ST-segment elevation myocardial infarction undergoing primary PCI.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholar.korea.ac.kr/handle/2021.sw.korea/93637)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.