Meta-analysis of associations between functional prolactin-1149 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus
- Authors
- Lee, Young Ho; Bae, Sang-Cheol; Song, Gwan Gyu
- Issue Date
- 4월-2015
- Publisher
- SPRINGER LONDON LTD
- Keywords
- Meta-analysis; Polymorphism; Prolactin; Rheumatoid arthritis; Systemic lupus erythematosus
- Citation
- CLINICAL RHEUMATOLOGY, v.34, no.4, pp.683 - 690
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL RHEUMATOLOGY
- Volume
- 34
- Number
- 4
- Start Page
- 683
- End Page
- 690
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/93912
- DOI
- 10.1007/s10067-015-2904-3
- ISSN
- 0770-3198
- Abstract
- The aim of this study was to determine whether the prolactin -1149 G/T polymorphism confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). A meta-analysis was conducted for examining the associations between prolactin -1149 G/T polymorphism and susceptibility to SLE or RA using allele contrast, recessive and dominant models, and homozygote contrast. A total of 10 comparative studies, consisting of 4 SLE and 6 RA studies, involving 4252 patients and 4949 controls, were included in the meta-analysis. No association between the prolactin -1149 G allele and SLE was found when all study subjects were considered together (OR = 1.019, 95 % CI = 1.841-1.236, p = 0.845). Stratification by ethnicity also indicated no association between the prolactin G allele and SLE in either Caucasian or Latin American populations. In contrast, a significant association was observed between the prolactin G allele and RA in all subjects (OR = 1.123, 95 % CI = 1.052-1.198, p = 4.6 x 10(-5)). After stratification by ethnicity, the G allele was found to be significantly associated with RA in Caucasians (OR = 1.112, 95 % CI = 1.041-1.189, p = 0.002). Furthermore, the prolactin -1149 G/T polymorphism was found to be associated with RA in Caucasians under the dominant model and under homozygote contrast. This meta-analysis demonstrates that the prolactin -1149 G/T polymorphism is associated with susceptibility to RA, but not SLE, in Caucasians.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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