Effect of Porcine Placenta Extract from Subcritical Water Extraction on Photodamage in Human Keratinocytes
DC Field | Value | Language |
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dc.contributor.author | Park, Yooheon | - |
dc.contributor.author | Han, Bok Kyung | - |
dc.contributor.author | Choi, Hyeon-Son | - |
dc.contributor.author | Hong, Yang Hee | - |
dc.contributor.author | Jung, Eun Young | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2021-09-04T17:42:20Z | - |
dc.date.available | 2021-09-04T17:42:20Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 1225-8563 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93968 | - |
dc.description.abstract | The objective of this study was to evaluated the photoprotective effects of porcine placenta extract (PPE) on ultraviolet B (UVB)-induced oxidative stress in human keratinocytes (HaCaT) to evaluate its functional activities as a skin food ingredient. PPE prepared by subcritical water extraction was termed SPE, and subsequently digested by enzymes to prepare E-SPE. Increased intracellular reactive oxygen species (ROS) levels (192.0%) induced by UVB were decreased by SPE and E-SPE. SPE had more effective ROS scavenging activity than E-SPE treatment. UVB treatment increased expression of tissue inhibitor of metalloproteinase 1 (TIMP-1), and this elevated expression was decreased by E-SPE treatment. High-dose treatment with E-SPE (50 and 100 mu g/mL) reduced TIMP-1 expression levels of UVB-C (control) to 33.5 and 34.6%, respectively. In contrast, at low SPE doses (1 and 10 mu g/mL), the treatment slightly decreased TIMP-1 expression levels to 73.3% and 71.3% of UVB-C, respectively. In conclusion, the present study demonstrated the protective effect of SPE and E-SPE against UVB damage in keratinocytes via ROS scavenging, down-regulating MMP-2 expression and up-regulating TIMP-1 expression. This highlights the potential for SPE as an ingredient in the preparation of functional food against photoaging. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC FOOD SCIENCE ANIMAL RESOURCES | - |
dc.subject | FLUID EXTRACTION | - |
dc.subject | RICE BRAN | - |
dc.subject | IN-VITRO | - |
dc.subject | GROWTH | - |
dc.subject | RADIATION | - |
dc.subject | PROLIFERATION | - |
dc.subject | INDUCTION | - |
dc.subject | PRODUCTS | - |
dc.subject | CELLS | - |
dc.title | Effect of Porcine Placenta Extract from Subcritical Water Extraction on Photodamage in Human Keratinocytes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.5851/kosfa.2015.35.2.164 | - |
dc.identifier.scopusid | 2-s2.0-84941645816 | - |
dc.identifier.wosid | 000357357800003 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES, v.35, no.2, pp.164 - 170 | - |
dc.relation.isPartOf | KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES | - |
dc.citation.title | KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES | - |
dc.citation.volume | 35 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 164 | - |
dc.citation.endPage | 170 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001988829 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | FLUID EXTRACTION | - |
dc.subject.keywordPlus | RICE BRAN | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | RADIATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | PRODUCTS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | porcine placenta extract | - |
dc.subject.keywordAuthor | subcritical water extraction | - |
dc.subject.keywordAuthor | UVB | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordAuthor | MMP-2 | - |
dc.subject.keywordAuthor | TIMP-1 | - |
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