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Effect of Porcine Placenta Extract from Subcritical Water Extraction on Photodamage in Human Keratinocytes

Authors
Park, YooheonHan, Bok KyungChoi, Hyeon-SonHong, Yang HeeJung, Eun YoungSuh, Hyung Joo
Issue Date
4월-2015
Publisher
KOREAN SOC FOOD SCIENCE ANIMAL RESOURCES
Keywords
porcine placenta extract; subcritical water extraction; UVB; ROS; MMP-2; TIMP-1
Citation
KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES, v.35, no.2, pp.164 - 170
Indexed
SCIE
SCOPUS
KCI
Journal Title
KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES
Volume
35
Number
2
Start Page
164
End Page
170
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/93968
DOI
10.5851/kosfa.2015.35.2.164
ISSN
1225-8563
Abstract
The objective of this study was to evaluated the photoprotective effects of porcine placenta extract (PPE) on ultraviolet B (UVB)-induced oxidative stress in human keratinocytes (HaCaT) to evaluate its functional activities as a skin food ingredient. PPE prepared by subcritical water extraction was termed SPE, and subsequently digested by enzymes to prepare E-SPE. Increased intracellular reactive oxygen species (ROS) levels (192.0%) induced by UVB were decreased by SPE and E-SPE. SPE had more effective ROS scavenging activity than E-SPE treatment. UVB treatment increased expression of tissue inhibitor of metalloproteinase 1 (TIMP-1), and this elevated expression was decreased by E-SPE treatment. High-dose treatment with E-SPE (50 and 100 mu g/mL) reduced TIMP-1 expression levels of UVB-C (control) to 33.5 and 34.6%, respectively. In contrast, at low SPE doses (1 and 10 mu g/mL), the treatment slightly decreased TIMP-1 expression levels to 73.3% and 71.3% of UVB-C, respectively. In conclusion, the present study demonstrated the protective effect of SPE and E-SPE against UVB damage in keratinocytes via ROS scavenging, down-regulating MMP-2 expression and up-regulating TIMP-1 expression. This highlights the potential for SPE as an ingredient in the preparation of functional food against photoaging.
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Suh, Hyung Joo
보건과학대학 (바이오시스템의과학부)
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