Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12
- Authors
- Lee, Miri; Park, Hyeonji; Jeon, Sea Wha; Bang, JeongKyu; Chung, Ka Young; Choi, Dal Woong; Kim, EunJoo; Lim, Kyung-Min
- Issue Date
- 4월-2015
- Publisher
- SPRINGER
- Keywords
- Peptoid; Melanogenesis; Zebrafish; 3D human skin models; Tyrosinase
- Citation
- ARCHIVES OF DERMATOLOGICAL RESEARCH, v.307, no.3, pp.249 - 257
- Indexed
- SCIE
SCOPUS
- Journal Title
- ARCHIVES OF DERMATOLOGICAL RESEARCH
- Volume
- 307
- Number
- 3
- Start Page
- 249
- End Page
- 257
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/94009
- DOI
- 10.1007/s00403-015-1555-1
- ISSN
- 0340-3696
- Abstract
- Diverse compound sources are being explored for de-pigmentation activities to develop novel therapeutic agents or functional cosmetic ingredients for hyper-pigmentation disorders. Peptoids are a class of peptidomimetics whose side chains are appended to the nitrogen atom of the peptide backbone, instead of alpha-carbon. Peptoids are more durable against proteolysis and are being actively investigated in drug discovery, but rarely studied as cosmetic ingredients. Here, we demonstrated that new hexa-peptoids, PAL-10 and PAL-12, can inhibit melanogenesis in B16F10 melanoma cells, a 3D pigmented human skin model (Neoderm(A (R))-ME, Tegoscience Co) and zebrafish. Anti-melanogenic effects of PAL-10 or PAL-12 as compared with arbutin, a positive control in B16F10 cells, Neoderm(A (R))-ME and zebrafish were statistically significant and concentration-dependent anti-melanogenic effects were manifested as determined by image, histology, and melanin contents. Anti-melanogenic effects of PAL-10 appeared to be from enzymatic inhibition of tyrosinase while mRNA expression of melanogenic enzymes was not affected. In conclusion, we demonstrated that PAL-10 and PAL-12 can be used as a new cosmetic ingredient with strong brightening efficacies.
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Collections - College of Health Sciences > School of Health and Environmental Science > 1. Journal Articles
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