An IgE-Mediated Allergic Reaction Caused by Mulberry Fruit
- Authors
- Choi, Jong Hyun; Sim, Jae Kyoem; Oh, Jee Youn; Hur, Gyu-Young; Min, Kyung Hoon; Lee, Sung Yong; Shim, Jae Jeong; Kang, Kyung Ho
- Issue Date
- Mar-2015
- Publisher
- KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
- Keywords
- Mulberry; allergen; food allergy; IgE
- Citation
- ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.7, no.2, pp.195 - 198
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
- Volume
- 7
- Number
- 2
- Start Page
- 195
- End Page
- 198
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/94198
- DOI
- 10.4168/aair.2015.7.2.195
- ISSN
- 2092-7355
- Abstract
- Mulberry (Morus spp.) is a widespread deciduous tree and its fruit is commonly eaten in Korea and eastern Asia. Some reports demonstrate that mulberry fruit is a food allergen in the Mediterranean area. However, there has been no report of systemic allergic reactions after ingesting mulberry fruit in Korea. An 18-year-old boy with a mulberry fruit allergy visited our allergy clinic. He had experienced generalized urticaria, chest tightness, breathing difficulty, and abdominal cramping after ingesting mulberry fruit. The patient had a positive skin reaction to mulberry fruit extract (mean wheal size, 5 mm). We performed an ELISA to detect specific IgE antibody (Ab) to mulberry fruit extract in the patient's serum compared to those of non-atopic healthy controls and birch-sensitized individuals. Specific IgE Ab to mulberry fruit extract was detected in the patient's serum, as compared to non-atopic healthy controls. Another subject, who was strongly sensitized to birch pollen, also had a positive serum-specific IgE Ab to mulberry fruit. We performed IgE immunoblot analysis using the patient's and the other subject's sera, who had serum-specific IgE to mulberry fruit, to identify the IgE-binding component. An identical IgE-binding component to mulberry extract was detected in the two subjects at around 17 kDa, and which might be PR 10 of Bet v 1. In conclusion, mulberry fruit could induce a systemic allergic reaction through an IgE-mediated mechanism, and cross-reactivity might occur between mulberry fruit and birch pollen.
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